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High-Dose Topical Zinc Oxide Promotes Healing Indices of Pressure Ulcers: A Pilot Randomized Clinical Trial Publisher Pubmed



R Fadaei RAYEHE ; A Larkiharchegani AMIR ; F Sajedi FIROZEH ; S Pourmoslemi SHABNAM ; S Khazaei SALMAN ; S Shabib SOMAYEH
Authors

Source: International Journal of Lower Extremity Wounds Published:2025


Abstract

Objective: Pressure ulcers seriously affect patient quality of life. The present study aimed to investigate the therapeutic effects of 25% zinc oxide topical cream on treating stage I and II pressure ulcers. Methods: This randomized, double-blind clinical trial involved 60 patients, divided into the control group (n = 30) receiving a silver-containing dressing and the intervention group (n = 30) treated with 25% zinc oxide cream. Wound assessments were conducted on days 0, 7, and 14, alongside standard care. Results: In the end, the intervention group showed significantly higher rates of “partial healing” and “peri-wound erythema reduction” than the control group (pvalue < .05). The intervention group's partial healing increased from 3.33% (day 7) to 83.34% (day 14) (pvalue < .05), whereas the control group reached from 26.67% to 60%. On day 14, the intervention group experienced a 50% decrease in peri-wound erythema, while the control group only experienced a 9.5% reduction (pvalue < .05). Also, 3.33% of the intervention group achieved complete healing, while none in the control group did. Conclusion: The findings suggest that 25% zinc oxide cream may function as an effective and cost-efficient alternative to conventional dressings in managing stage I and II pressure ulcers. © 2025 Elsevier B.V., All rights reserved.
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