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Efficacy of Topical Atorvastatin for the Treatment of Pressure Ulcers: A Randomized Clinical Trial Publisher Pubmed



Farsaei S1, 2 ; Khalili H1 ; Farboud ES3 ; Karimzadeh I1 ; Beigmohammadi MT4
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, P.O. Box 14155/6451, Iran
  2. 2. Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Faculty of Pharmacy, Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anesthesiology and Critical Care Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Pharmacotherapy Published:2014


Abstract

STUDY OBJECTIVE To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients. DESIGN Randomized, double-blind, placebo-controlled clinical trial. SETTING Medical-surgical intensive care unit of a university-affiliated teaching hospital in Tehran, Iran. PATIENTS One hundred four patients with stage I or II pressure ulcers, graded according to the 2-digit Stirling Pressure Sore Severity Scale. INTERVENTION Patients were randomized to receive topical atorvastatin 1% ointment (51 patients [atorvastatin group]) or placebo ointment (53 patients [control group]) applied once/day to pressure ulcers for 14 days in addition to standard care for pressure ulcers. MEASUREMENTS AND MAIN RESULTS The efficacy of each treatment was assessed on days 7 and 14. Efficacy was determined based on the degree of healing of the existing pressure ulcer by using the 2-digit Stirling scale. The baseline stage of the pressure ulcers did not differ significantly between the control and atorvastatin groups. However, the mean ± SD stage of pressure ulcers significantly decreased in the atorvastatin group compared with the control group on day 7 (0.97 ± 0.76 vs 1.74 ± 0.75, p<0.01) and day 14 (0.42 ± 0.67 vs 1.71 ± 0.78, p<0.01) of treatment. In addition, the mean ± SD surface areas of ulcers in the atorvastatin group were significantly declined compared with the control group after 7 days (5.55 ± 4.55 vs 9.41 ± 5.03 cm 2, p<0.01) and 14 days (3.72 ± 4.45 vs 10.41 ± 6.41 cm2, p<0.01) of treatment. CONCLUSION Topical application of atorvastatin ointment 1% for 14 days in addition to standard care significantly accelerated the healing of stage I or II pressure ulcers in critically ill patients. © 2013 Pharmacotherapy Publications, Inc.
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