Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Utilizing Stem Cells in Reconstructive Treatments for Sports Injuries: An Innovative Approach Publisher Pubmed



Yu H1 ; Habibi M2, 3, 4 ; Motamedi K5 ; Semirumi DT6 ; Ghorbani A7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Physical Education Department, Jingchu University of Technology, Hubei, Jingmen, 448000, China
  2. 2. Faculty of Architecture and Urbanism, UTE University, Calle Rumipamba S/N and Bourgeois, Quito, Ecuador
  3. 3. Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, 600 077, India
  4. 4. Institute of Research and Development, Duy Tan University, Da Nang, 550000, Viet Nam
  5. 5. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Biomaterials, Islamic Azad University, Isfahan, Iran
  7. 7. Biotechnology Department, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Source: Tissue and Cell Published:2023


Abstract

Orthopedic tissue engineering is a rapidly evolving field that holds great promise for the reconstruction and natural repair of bone and joint tissues. Bone loss, fractures, and joint degeneration are common problems that can result from a variety of pathological conditions, and their restoration and replacement are essential not only for functional purposes but also for improving the quality of life for patients. However, current methods rely heavily on artificial materials that can potentially lead to further tissue damage, making tissue engineering a highly attractive alternative. This innovative approach involves the utilization of stem cells (SCs), which are seeded onto a scaffold to form a biological complex. Among these SCs, mesenchymal stem cells (MSCs) extracted from bone marrow and adipose tissue have shown immense potential for bone and joint tissue regeneration. The success of orthopedic tissue engineering is contingent on the careful selection of appropriate scaffolds and inducing molecules, which play a critical role in carrying and supporting cells and inducing their differentiation. This review article comprehensively analyzes the three vital aspects of orthopedic tissue engineering - SCs, scaffolds, and inducing molecules - in order to provide a deeper understanding of this emerging field and its potential for the future of orthopedic medicine. © 2023 Elsevier Ltd
Related Docs
View other Related Docs
1. Tissue Engineering: Dentin – Pulp Complex Regeneration Approaches (A Review), Tissue and Cell (2017)
2. Stem Cells in Dentistry, Sources, and Applications, Dental Hypotheses (2016)
3. Effect of Polyhydroxybutyrate/Chitosan/Bioglass Nanofiber Scaffold on Proliferation and Differentiation of Stem Cells From Human Exfoliated Deciduous Teeth Into Odontoblast-Like Cells, Materials Science and Engineering C (2018)
4. Poly (Glycerol Sebacate) and Polyhydroxybutyrate Electrospun Nanocomposite Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells, Journal of Drug Delivery Science and Technology (2021)
5. Electrospun Polycaprolactone/Lignin-Based Nanocomposite As a Novel Tissue Scaffold for Biomedical Applications, Journal of Medical Signals and Sensors (2017)
6. Review of Recent Advances in Bone Scaffold Fabrication Methods for Tissue Engineering for Treating Bone Diseases and Sport Injuries, Tissue and Cell (2024)
7. Transplantation of Undifferentiated and Induced Human Exfoliated Deciduous Teeth-Derived Stem Cells Promote Functional Recovery of Rat Spinal Cord Contusion Injury Model, Stem Cells and Development (2012)
8. A Review on the Effect of Nanocomposite Scaffolds Reinforced With Magnetic Nanoparticles in Osteogenesis and Healing of Bone Injuries, Stem Cell Research and Therapy (2023)
Experts (# of related papers)
View all Related Experts
Batool Hashemibeni (47)
Saeed Karbasi (35)
Other Related Docs
9. Investigation of the Behavior of Different Ni-Ti Dental Files and Chemical Mechanical Behavior Using Finite Element Analysis, Nanochemistry Research (2022)
10. Investigation of Metallic 3D Porous Scaffold Prepared by Selective Lasintering for Dental Applications, Nanochemistry Research (2023)
11. A Brief Review of the Structure Designed Using Metallic 3D Printing for Biomechanics Applications, Additive Manufacturing for Biocomposites and Synthetic Composites (2023)
12. Investigation of Addition of Calcium Phosphate Ceramic to Multilayer Scaffold for Bone Applications With Improved Mechanical Properties: Fuzzy Logic Analysis, Ceramics International (2023)
13. Cytotoxicity Assessment of Polyhydroxybutyrate/Chitosan/Nano- Bioglass Nanofiber Scaffolds by Stem Cells From Human Exfoliated Deciduous Teeth Stem Cells From Dental Pulp of Exfoliated Deciduous Tooth, Dental Research Journal (2018)
14. Incorporation of Chitosan Nanoparticles Into Silk Fibroin-Based Porous Scaffolds: Chondrogenic Differentiation of Stem Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2016)
15. Immunomodulation in Bone Tissue Engineering: Recent Advancements in Scaffold Design and Biological Modifications for Enhanced Regeneration, ACS Biomaterials Science and Engineering (2025)
16. The Molecular Perspective on the Melanoma and Genome Engineering of T-Cells in Targeting Therapy, Environmental Research (2023)
17. 3D Micro-Nano Structured Hybrid Scaffolds: An Investigation Into the Role of Nanofiber Coating on Viability, Proliferation and Differentiation of Seeded Mesenchymal Stem Cells, Journal of Nanoscience and Nanotechnology (2016)
18. Pcl/Col I-Based Magnetic Nanocomposite Scaffold Provides an Osteoinductive Environment for Adscs in Osteogenic Cues-Free Media Conditions, Stem Cell Research and Therapy (2022)
19. Bioceramic Calcium Phosphate-Polymer Scaffolds: A Promising Strategy for Osteochondral Repair and Regenerative Medicine, Materials Chemistry and Physics (2023)
20. Regeneration or Replacement? a Case Report and Review of Literature, Dental Traumatology (2016)
21. Comparison of Fibrin and Plga/Fibrin Scaffolds for Chondrogenesis of Human Adipose Derived Stem Cells by Icariin, Journal of Kerman University of Medical Sciences (2020)
22. Chondrogenesis of Human Adipose-Derived Mesenchymal Stromal Cells on the [Devitalized Costal Cartilage Matrix/Poly(Vinyl Alcohol)/Fibrin] Hybrid Scaffolds, European Polymer Journal (2019)
23. Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes As a Cell-Free Therapy Approach for the Treatment of Skin, Bone, and Cartilage Defects, Connective Tissue Research (2022)
24. Study of Carbon Nano-Tubes Effects on the Chondrogenesis of Human Adipose Derived Stem Cells in Alginate Scaffold, International Journal of Preventive Medicine (2014)
25. The Journey of Multifunctional Bone Scaffolds Fabricated From Traditional Toward Modern Techniques, Bio-Design and Manufacturing (2020)
26. Comparison Between Chondrogenic Markers of Differentiated Chondrocytes From Adipose Derived Stem Cells and Articular Chondrocytes in Vitro, Iranian Journal of Basic Medical Sciences (2013)
27. Evaluation of the Mechanical Characteristics of Plga and Plga/Fibrin Scaffolds in Providing an Appropriate Environment for Viability and Growth of Human Adipose-Derived Stem Cells, Eurasian Journal of Analytical Chemistry (2018)
28. Effects of Cartilage Acellular Solubilised Ecm on Physicomechanical and Biological Properties of Polycaprolactone/Fibrin Hybrid Scaffold Fabricated by 3D-Printing and Salt-Leaching Methods, Materials Technology (2022)
29. Chondrogenesis of Mesenchymal Stromal Cells on the 3D Printed Polycaprolactone/Fibrin/Decellular Cartilage Matrix Hybrid Scaffolds in the Presence of Piascledine, Journal of Biomaterials Science, Polymer Edition (2024)
30. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
31. Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells, Journal of Biomaterials Science, Polymer Edition (2022)
32. Herbal Remedies As Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies, Molecules (2020)
33. Hybrid and Composite Scaffolds Based on Extracellular Matrices for Cartilage Tissue Engineering, Tissue Engineering - Part B: Reviews (2019)
34. Comparing the Effects of Transforming Growth Factor Beta1 (Tgf-ß1) and Piascledine on the Expression of Collagen Ii, X and Aggrecan Genes in Chondrogenesis of Human Adipose-Derived Stem Cells in Fibrin Alginate Composite Scaffold, Journal of Isfahan Medical School (2016)
35. Isolation of Mesenchymal Stem Cells From Dental Pulp of Exfoliated Human Deciduous Teeth, Yakhteh (2008)
36. Adipose-Derived Stem Cells Combined With Beta-Tricalcium Phosphate: A Novel Possible Strategy for Periodontal Defects Regeneration, Medical Hypotheses (2014)
37. Highly Porous 3D Printed Scaffold Incorporated With Graphene Oxide-Merwinite and Coated With Igf1 Loaded Nanofibers for Calvarial Defect Repair, Journal of Polymers and the Environment (2024)
38. Sodium Alginate/Magnesium Oxide Nanocomposite Scaffolds for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
39. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
40. Investigation and Comparison of the Effect of Tgf-Β3, Kartogenin and Avocado/Soybean Unsaponifiables on the In-Vitro and In-Vivo Chondrogenesis of Human Adipose-Derived Stem Cells on Fibrin Scaffold, Iranian Journal of Pharmaceutical Research (2021)
41. Fabrication and Characterization of Chitosan-Gelatin/Single-Walled Carbon Nanotubes Electrospun Composite Scaffolds for Cartilage Tissue Engineering Applications, Polymers for Advanced Technologies (2022)
42. A Novel Flexible, Conductive, and Three-Dimensional Reduced Graphene Oxide/Polyurethane Scaffold for Cell Attachment and Bone Regeneration, Materials and Design (2022)
43. Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
44. Cartilage Tissue Formation From Human Adipose-Derived Stem Cells Via Herbal Component (Avocado/Soybean Unsaponifiables) in Scaffold-Free Culture System, Dental Research Journal (2020)
45. Effects of Low-Intensity Pulsed Ultrasound Stimulation on Cell Seeded 3D Hybrid Scaffold As a Novel Strategy for Meniscus Regeneration: An in Vitro Study, Journal of Tissue Engineering and Regenerative Medicine (2022)
46. An Animal Model Study of Osteochondral Defect Repair by Human Adipose Stem Cells and Pomegranate Fruit Hydroalchoholic Extract, Avicenna Journal of Phytomedicine (2023)
47. Combination Therapy of Metadichol Nanogel and Lipocalin-2 Engineered Mesenchymal Stem Cells Improve Wound Healing in Rat Model of Excision Injury, Advanced Pharmaceutical Bulletin (2022)
48. A Comparison Between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and Ph, Iranian Polymer Journal (English Edition) (2005)
49. Induction of Neuron-Like Cells From Adipose Derived Stem Cells in Alginate Hydrogel, Using Neurospheres Formation, Journal of Isfahan Medical School (2014)
50. Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs, Polymers (2022)