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Isfahan Covid Cohort Study: Rationale, Methodology, and Initial Results Publisher

Summary: A study found 60% of COVID-19 patients face persistent symptoms like joint pain, urging long-term care. #COVID19 #LongCOVID

Sarrafzadegan N1, 2 ; Mohammadifard N1 ; Javanmard SH3 ; Haghighatdoost F4 ; Nouri F5 ; Ahmadian M6 ; Nasirian M7 ; Sayyah M8 ; Najafian J4 ; Shafiei M1 ; Alikhasi H9 ; Javanbakht S10 ; Nilforoushzadeh F1 ; Bagheri F1 Show All Authors
Authors
  1. Sarrafzadegan N1, 2
  2. Mohammadifard N1
  3. Javanmard SH3
  4. Haghighatdoost F4
  5. Nouri F5
  6. Ahmadian M6
  7. Nasirian M7
  8. Sayyah M8
  9. Najafian J4
  10. Shafiei M1
  11. Alikhasi H9
  12. Javanbakht S10
  13. Nilforoushzadeh F1
  14. Bagheri F1
  15. Shahidi S1
  16. Rezaei M11
  17. Heidari K12
  18. Keleidari B13
  19. Changiz T14

Source: Journal of Research in Medical Sciences Published:2022


Abstract

Background: The Isfahan COVID Cohort (ICC) study was designed to investigate the short- and long-term consequences of patients with COVID-19 in Iran. This report presents the rationale, methodology, and initial results of ICC. Materials and Methods: ICC is a 5-year multicentric prospective cohort study that is ongoing on two groups including 5000 patients hospitalized with moderate or severe and 800 nonhospitalized patients with mild or asymptomatic COVID-19 in Isfahan. The ICC endpoints are morbidity, mortality, incident cases, or worsening of underlying noncommunicable diseases (NCDs) and their risk factors. In the current analysis, we examined the persistent symptoms and incident NCDs or risk factors in 819 previously hospitalized patients who completed 1-year follow-up. Results: The two most common symptoms were joint pain/myalgia (19.7%) and dry cough/dyspnea (18.7%). Around 60% of patients had at least one symptom which was more common among women than men and in middle aged than younger or older patients. Female (odds ratio [OR] =1.88, 95% confidence interval [CI]: 1.39-2.55) and highly-educated patients (OR = 2.18, 95% CI: 1.56-3.04) had higher risk of having any symptom in 1-year follow-up. New cases of hypertension followed by diabetes then coronary heart disease (CHD) were the most common incident NCDs. Conclusion: During 1-year follow-up after hospital discharge, about 60% of patients experienced persistent symptoms. Incident hypertension, diabetes, and CHD were the most common events seen. Close monitoring and extensive health services with integrative approaches are needed to improve the health status of these patients. © 2022 Journal of Research in Medical Sciences | Published by Wolters Kluwer - Medknow.
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