Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Surface Modification on the Mechanical and Structural Properties of Nanofibrous Poly(Ε-Caprolactone)/Forsterite Scaffold for Tissue Engineering Applications Publisher Pubmed



Kharaziha M1 ; Fathi MH1, 3 ; Edris H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran
  3. 3. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Materials Science and Engineering C Published:2013


Abstract

Composite scaffolds consisting of polymers reinforced with ceramic nanoparticles are widely applied for hard tissue engineering. However, due to the incompatible polarity of ceramic nanoparticles with polymers, they tend to agglomerate in the polymer matrix which results in undesirable effects on the integral properties of composites. In this research, forsterite (Mg 2SiO4) nanoparticles was surface esterified by dodecyl alcohol and nanofibrous poly(ε-caprolactone)(PCL)/modified forsterite scaffolds were developed through electrospinning technique. The aim of this research was to investigate the properties of surface modified forsterite nanopowder and PCL/modified forsterite scaffolds, before and after hydrolytic treatment, as well as the cellular attachment and proliferation. Results demonstrated that surface modification of nanoparticles significantly enhanced the tensile strength and toughness of scaffolds upon 1.5-and 4-folds compared to unmodified samples, respectively, due to improved compatibility between matrix and filler. Hydrolytic treatment of scaffolds also modified the bioactivity and cellular attachment and proliferation due to greatly enhanced hydrophilicity of the forsterite nanoparticles after this process compared to surfacemodified samples. Results suggested that surface modification of forsterite nanopowder and hydrolytic treatment of the developed scaffolds were effective approaches to address the issues in the formation of composite fibers and resulted in development of bioactive composite scaffoldswith ideal mechanical and structural properties for bone tissue engineering applications. © 2013 Elsevier B.V. All rights reserved.
Related Docs
View other Related Docs
1. Development of Novel Aligned Nanofibrous Composite Membranes for Guided Bone Regeneration, Journal of the Mechanical Behavior of Biomedical Materials (2013)
2. Tunable Cellular Interactions and Physical Properties of Nanofibrous Pcl-Forsterite: Gelatin Scaffold Through Sequential Electrospinning, Composites Science and Technology (2013)
3. The Thickness of Electrospun Poly (Ε-Caprolactone Nanofibrous Scaffolds Influences Cell Proliferation, International Journal of Artificial Organs (2009)
4. Synthesis and Characterization of Bioactive Glass Coated Forsterite Scaffold for Tissue Engineering Applications, Journal of Alloys and Compounds (2017)
5. Formulation of Electrospun Mg-Fa/Poly (Ε-Caprolactone) Nanocomposite to Adjust Bioactivity, Biodegradability, and Cellular Interactions, Polymers for Advanced Technologies (2021)
6. Mechanical and Cytotoxicity Evaluation of Nanostructured Hydroxyapatite-Bredigite Scaffolds for Bone Regeneration, Materials Science and Engineering C (2016)
7. Preparation and Biocompatibility Evaluation of Bioactive Glass-Forsterite Nanocomposite Powder for Oral Bone Defects Treatment Applications, Materials Science and Engineering C (2015)
8. Surface Modification of Mg-Doped Fluoridated Hydroxyapatite Nanoparticles Using Bioactive Amino Acids As the Coupling Agent for Biomedical Applications, Ceramics International (2015)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (87)
Mohammad Rafienia (54)
Other Related Docs
9. Ultra-Fast, Highly Efficient and Green Synthesis of Bioactive Forsterite Nanopowder Via Microwave Irradiation, Materials Science and Engineering C (2018)
10. A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold With Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies, Journal of the European Ceramic Society (2021)
11. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
12. Electrospun Polycaprolactone/Lignin-Based Nanocomposite As a Novel Tissue Scaffold for Biomedical Applications, Journal of Medical Signals and Sensors (2017)
13. Novel Electrospun Polyurethane Scaffolds Containing Bioactive Glass Nanoparticles, Bioinspired, Biomimetic and Nanobiomaterials (2020)
14. The Electrospun Poly(Ε-Caprolactone)/Fluoridated Hydroxyapatite Nanocomposite for Bone Tissue Engineering, Polymers for Advanced Technologies (2020)
15. Hierarchical Porous Mg2sio4-Cofe2o4 Nanomagnetic Scaffold for Bone Cancer Therapy and Regeneration: Surface Modification and in Vitro Studies, Materials Science and Engineering C (2020)
16. 3D Printed Magnetoactive Nanocomposite Scaffolds for Bone Regeneration, Biomedical Materials (Bristol) (2025)
17. Preparing Nanocomposite Fibrous Scaffolds of P3hb/Nha for Bone Tissue Engineering, 2010 17th Iranian Conference of Biomedical Engineering, ICBME 2010 - Proceedings (2010)
18. Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies, Polymers for Advanced Technologies (2020)
19. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)
20. Effects of Adding Forsterite Bioceramic on in Vitro Activity and Antibacterial Properties of Bioactive Glass-Forsterite Nanocomposite Powders, Advanced Powder Technology (2016)
21. A Ternary Nanocomposite Fibrous Scaffold Composed of Poly(Ε-Caprolactone)/Gelatin/Gehlenite (Ca2al2sio7): Physical, Chemical, and Biological Properties in Vitro, Polymers for Advanced Technologies (2021)
22. Effects of Nano-Bioactive Glass on Structural, Mechanical and Bioactivity Properties of Poly (3-Hydroxybutyrate) Electrospun Scaffold for Bone Tissue Engineering Applications, Materials Technology (2019)
23. Zn-Substituted Mg2sio4 Nanoparticles-Incorporated Pcl-Silk Fibroin Composite Scaffold: A Multifunctional Platform Towards Bone Tissue Regeneration, Materials Science and Engineering C (2021)
24. Characterization of Poly(Ε-Caprolactone)/Extracellular Matrix Nanofibers Composite Scaffold for Tissue Engineering, Journal of Isfahan Medical School (2019)
25. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
26. Fabrication and Characterization of Two-Layered Nanofibrous Membrane for Guided Bone and Tissue Regeneration Application, Materials Science and Engineering C (2017)
27. Porous Titanium Scaffold Coated Using Forsterite/Poly-3-Hydroxybutyrate Composite for Bone Tissue Engineering, Surface and Coatings Technology (2019)
28. Effect of Forsterite Nanoparticles on Mechanical Properties of Glass Ionomer Cements, Ceramics International (2014)
29. A Novel Nano-Composite Scaold for Cartilage Tissue Engineering, Scientia Iranica (2018)
30. Pcl-Forsterite Nanocomposite Fibrous Membranes for Controlled Release of Dexamethasone, Journal of Materials Science: Materials in Medicine (2015)
31. Fabrication and Characterization Nanostructured Forsterite Foams With High Compressive Strength, Desired Porosity and Suitable Bioactivity for Biomedical Applications, Journal of Sol-Gel Science and Technology (2017)
32. In Vitro Characterisation of a Sol–Gel Derived in Situ Silica-Coated Silicate and Carbonate Co-Doped Hydroxyapatite Nanopowder for Bone Grafting, Materials Science and Engineering C (2017)
33. Surfactant-Assisted Sol-Gel Synthesis of Forsterite Nanoparticles As a Novel Drug Delivery System, Materials Science and Engineering C (2016)
34. Evaluation of Physical and Mechanical Properties of Fi-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nanocomposite Scaffold for Bone Tissue Engineering Application, Scientia Iranica (2017)
35. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
36. Polycaprolactone-Chitosan/Multi-Walled Carbon Nanotube: A Highly Strengthened Electrospun Nanocomposite Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
37. Implementing Taguchi Method to Analyze Electrospinning Parameters Influence on Mg-Doped Fluorapatite Nanoparticles-Poly (Ε-Caprolactone) Nanocomposite Scaffold (Mg-Fa Nps/Pcl) Properties, Polymers for Advanced Technologies (2020)
38. Novel Electrophoretic Deposited Nanostructured Forsterite Coating on 316L Stainless Steel Implants for Biocompatibility Improvement, Materials Letters (2015)
39. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
40. Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells, Journal of Biomaterials Science, Polymer Edition (2022)
41. Preparation of Fibrin/Poly Vinyl Alcohol Electrospun Nanofibers Scaffold for Tissue Engineering Applications, Journal of Isfahan Medical School (2016)
42. Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
43. Baghdadite/Polycaprolactone Nanocomposite Scaffolds: Preparation, Characterisation, and in Vitro Biological Responses of Human Osteoblast-Like Cells (Saos-2 Cell Line), Materials Technology (2020)
44. Nanobiomaterials in Periodontal Tissue Engineering, Nanobiomaterials in Hard Tissue Engineering: Applications of Nanobiomaterials (2016)
45. A New Approach to Fabrication of Cs/Bg/Cnt Nanocomposite Scaffold Towards Bone Tissue Engineering and Evaluation of Its Properties, Applied Surface Science (2015)
46. Poly Glycerol Sebacate/ Polycaprolactone/ Carbon Quantum Dots Fibrous Scaffold As a Multifunctional Platform for Cardiac Tissue Engineering, Materials Chemistry and Physics (2021)
47. Potential of an Electrospun Composite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Alumina Nanowires in Bone Tissue Engineering Applications, Materials Science and Engineering C (2019)
48. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
49. Incorporation of Multi-Walled Carbon Nanotubes Into Electrospun Pcl/Gelatin Scaffold: The Influence on the Physical, Chemical and Thermal Properties and Cell Response for Tissue Engineering, Materials Technology (2020)
50. Physical, Mechanical, and Biological Performance of Chitosan-Based Nanocomposite Coating Deposited on the Polycaprolactone-Based 3D Printed Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)