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Formulation of Electrospun Mg-Fa/Poly (Ε-Caprolactone) Nanocomposite to Adjust Bioactivity, Biodegradability, and Cellular Interactions Publisher



Fereshteh Z1, 2, 3 ; Fathi M3, 4 ; Kargozar S5 ; Samadikuchaksaraei A6, 7, 8
Authors

Source: Polymers for Advanced Technologies Published:2021


Abstract

Adjusting the biological properties of scaffolds is one of the most challenging issues in tissue engineering. Here, we focus on formulating a nanocomposite with tunability for bioactivity, biodegradability, and cellular interactions by using different nanoparticles composition and concentration. Here, after optimizing Mg+2 ions concentration in fluorapatite nanoparticles (Mg-FA NPs), we probed the influence of Mg-FA NPs on the biological properties of the electrospun Mg-FA/poly (ε-caprolactone). Increasing Mg-FA nanoparticles up to 15 wt% in the composite could enhance the bioactivity from 0.02 wt% in the pure PCL scaffold up to 3 wt% (150 times more) by gaining weight after 28-day incubation in simulated body fluid (SBF) at 37°C. In the same order, the biodegradation of scaffolds accelerated from 3.1 wt% to 34.6 wt% (11 times more). The cell attachment assays, using MG-63, showed that the presence of Mg-FA NPs plays a crucial role to attach cells on the surface by improving wettability as well as biocompatibility. Also, the Mg-FA NPs encouraged MG-63 cells to proliferate on/inside the scaffolds and generate 3D cell networks. © 2021 John Wiley & Sons Ltd.
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