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Intravitreal Vascular Endothelial Growth Factor (Vegf) Inhibitor Injection in Unrecognised Early Pregnancy Publisher Pubmed



Kianersi F1 ; Ghanbari H1 ; Naderi Beni Z2 ; Naderi Beni A3
Authors
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Authors Affiliations
  1. 1. Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Oncology and Radiotherapy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Ophthalmology, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Investigational New Drugs Published:2016


Abstract

The use of intravitreal vascular endothelial growth factor (VEGF) inhibitor medications has widened considerably to include indications affecting females of reproductive age. Our patient was inadvertently exposed to bevacizumab within the first trimester when placental growth and fetal organogenesis take place and patient suffered pregnancy loss. There is insufficient information to suggest that such use is safe, nor is there definitive evidence to suggest that it causes harm. We advise that ophthalmologists discuss pregnancy with women of childbearing age undergoing intraocular anti-VEGF injections and in pregnant woman counselling is needed to explain the potential risks and benefits. © 2016, Springer Science+Business Media New York.