Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Dextromethorphan on Reducing Methadone Dosage in Opium Addicts Undergoing Methadone Maintenance Therapy: A Double Blind Randomized Clinical Trial



Salehi M1 ; Ramezani MA2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Cancer Control, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2011

Abstract

BACKGROUND: Dextromethorphan (DM) is an N-methyl-D-aspartate (NMDA) receptor antagonist that may be useful during opiate addiction process, especially in reducing methadone consumption in methadone maintenance therapy (MMT). The goal of the current study was to evaluate the effects of oral administration of DM on reducing methadone dose in MMT used to treat illicit opioid drug abuse. METHODS: A double-blinded randomized clinical trial was designed. Seventy two opiate abusers undergoing MMT were randomly divided into two groups. Participants in the intervention group were medicated by DM while those in the control group received placebo. After a 6-week follow-up, methadone consumption dosage, quality of life (QOL) and withdrawal symptoms were assessed and compared between the two groups by repeated measure ANOVA statistical test. RESULTS: The mean of methadone consumption in the DM and control groups were 62.7 mg/day (52.7-72.7) and 70.4 mg/day (60.4-80.4), respectively. No statistically significant difference was found between the two groups among the four evaluations made (F = 1.192, P = 0.279). There were not any significant differences in withdrawal symptoms between the two groups (P > 0.05). Total mean scores of QOL in the intervention and control groups were 84.8 (78.7- 90.8) and 77.8 (71.8-83.7) (P > 0.05), respectively. CONCLUSIONS: Although DM might be useful for opioid dependence treatment, results of the current study did not reveal any statistically significant differences. Therefore, further studies exploring this possibility are needed.
Related Docs
View other Related Docs
1. Tramadol Versus Methadone for the Management of Acute Opioid Withdrawal: An Add-On Study, Journal of Research in Medical Sciences (2006)
2. Ginseng Treatment Improves the Sexual Side Effects of Methadone Maintenance Treatment, Psychiatry Research (2019)
3. Opium Tincture Versus Methadone for Opioid Agonist Treatment: A Randomized Controlled Trial, Addiction (2023)
4. Effectiveness of Relapse Prevention Cognitive- Behavioral Model in Opioid -Dependent Patients Participating in the Methadone Maintenance Treatment in Iran, Iranian Journal of Public Health (2013)
5. Predictors of Treatment Retention in a Major Methadone Maintenance Treatment Program in Iran: A Survival Analysis, Journal of Research in Health Sciences (2014)
6. Investigating the Effect of Zinc Supplementation on Probability of Relapse and Mental Health in Patients With Opioid Use Disorder Undergoing Methadone Maintenance Treatment, Substance Abuse: Treatment, Prevention, and Policy (2023)
7. Comparing Opium Tincture and Methadone for Medication-Assisted Treatment of Patients With Opioid Use Disorder: Protocol for a Multicenter Parallel Group Noninferiority Double-Blind Randomized Controlled Trial, International Journal of Methods in Psychiatric Research (2019)
8. Investigating the Relation of Drug Abusing and Oral Health in Addicts, Journal of Isfahan Medical School (2015)
Experts (# of related papers)
View all Related Experts
Gholam Reza Kheirabadi (12)
Hojatallah Alaei (10)
Other Related Docs
9. The Effect of Adding Memantine to Clonidine in Reducing Withdrawal Symptoms in Opioid-Dependent Patients: A Double-Blind Randomized Controlled Trial, Journal of Clinical Psychopharmacology (2021)
10. The Effects of Oxytocin on Craving, Mental Health Parameters, and Stress Hormones in Methamphetamine-Dependent Patients Undergoing Matrix Treatment Model: A Randomized, Double-Blind Clinical Trial, European Addiction Research (2022)
11. Importance of Gabapentin Dose in Treatment of Opioid Withdrawal, Journal of Clinical Psychopharmacology (2011)
12. Bupropion Efficacy on Sexual Dysfunction Among Male Patients on Methadone Maintenance Therapy: A Double-Blind Placebo-Controlled Trial, Sexual and Relationship Therapy (2015)
13. The Effect of Buprenorphine on Methamphetamine Cravings, Journal of Clinical Psychopharmacology (2015)
14. Effects of Roy's Adaptation Model on Quality of Life in People With Opioid Abuse Under Methadone Maintenance Treatment: A Randomized Trial, Ethiopian journal of health sciences (2023)
15. Is Opium Addiction a Risk Factor for Deep Vein Thrombosis? a Case-Control Study, Blood Coagulation and Fibrinolysis (2010)
16. Perceived Barriers to Methadone Maintenance Treatment Among Iranian Opioid Users, International Journal for Equity in Health (2018)
17. The Effect of Perphenazine Add-On Therapy to Matrix Intervention on Control of Craving and Relapse in Methamphetamine Users: A Randomized Controlled Trial, International Journal of High Risk Behaviors and Addiction (2022)
18. Comparison of the Efficacy of Methadone and Tramadol in Opioid-Assisted Detoxification, Iranian Journal of Medical Sciences (2007)
19. Naltrexone in Unintentional Methadone Poisoning, Journal of Isfahan Medical School (2016)
20. Risk Factors for Opioids and Stimulants Poisoning Among Patients Admitted to Khorshid Hospital in Isfahan, Journal of Isfahan Medical School (2022)
21. Social Cognitive Theory As a Theoretical Framework to Predict Sustained Abstinence 6 Months After Substance Use Treatment, Journal of Substance Use (2018)
22. The Effect of Short-Term Physical Activity on Withdrawal Symptoms With or Without Mpfc Area in Male Rats Influenced by Morphine, Journal of Isfahan Medical School (2013)
23. Personality Traits and Their Relationship to Demographic Features in Addicts Referring to a Drug Rehabilitation Center in the City of Isfahan, Iran, Iranian Journal of Public Health (2015)
24. Effect of Methadone Maintenance Therapy on Sexual Disorders in Males: A Systematic Review and Meta-Analysis, Sexual Medicine Reviews (2024)
25. Evaluation of Medical Prefrontal Cortex (Mpfc) Stimulation and Destruction Effects on Addiction to Morphine, Journal of Isfahan Medical School (2013)
26. Microinjection of a Dopamine-D1 Receptor Agonist Into the Ventral Tegmental Area Reverses the Blocked Expression of Morphine Conditioned Place Preference by N-Methyl-D-Aspartate Receptor Antagonist, Advanced Biomedical Research (2020)
27. Pregabalin Does Not Reduce Opioid Withdrawal Symptoms: A Randomized Controlled Trial, Addictive Disorders and their Treatment (2019)
28. Blockade of Prelimbic Glutamate Receptor Reduces the Reinforcing Effect of Morphine, Canadian Journal of Physiology and Pharmacology (2018)
29. Comparison of the Effect of Intravenous Fentanyl With Low-Dose Ketamine on Pain Relief in Patients Taking Methadone and Suffering From Limb Fractures, Advanced Biomedical Research (2023)
30. Prevalence of Gastrointestinal Symptoms in Opioid Consumers Referring to Methadone Maintenance Treatment (Mmt) Clinics in Isfahan, Iran, Journal of Isfahan Medical School (2013)
31. Prevalence, Reasons, and Prevention for Drug Related Death After Release From Prisons: A Systematic Review and Meta-Analysis, Middle East Journal of Rehabilitation and Health Studies (2025)
32. Risk and Protective Factors Affecting Drug Craving Among Patients With Substance Use Disorders Undergoing Opioid Agonists Maintenance Therapy, Substance Use and Misuse (2023)
33. The Prevalence Rate of Substance Abuse in Applicants for Marriage in Isfahan Province, Iran, From 2013 to 2017, Journal of Isfahan Medical School (2020)
34. Demographic Factors, Duration of Hospitalization, Costs of Hospitalization, and Cause of Death in Patients Intoxicated With Amphetamines and Opioids, Journal of Isfahan Medical School (2011)
35. Executive Functions in Methamphetamine and Heroin Users Versus Non-Users, Journal of Isfahan Medical School (2013)
36. Effect of a Nursing Care Program Based on Roy's Adaptation Model on Sleep Quality in Patients Undergoing Methadone Maintenance Treatment: A Randomized Clinical Trial, HAYAT (2024)
37. Redemption From Plight: A Qualitative Study on Reasons Behind Treatment Decisions Among Iranian Male Opioid Users, Substance Abuse: Treatment, Prevention, and Policy (2020)
38. The Efficacy of Plissit As Adjuvant Therapy With Bupropion on Sexual Dysfunction and Marital Satisfaction Among Men Patients on Methadone Maintenance Therapy, Journal of Isfahan Medical School (2018)
39. Predictors of Time to Relapse in Amphetamine-Type Substance Users in the Matrix Treatment Program in Iran: A Cox Proportional Hazard Model Application, BMC Psychiatry (2016)
40. The Effect of Matrix Model on Depression, Anxiety, and Quality of Life in Methamphetamine Users and Their Caregivers, Addictive Disorders and their Treatment (2018)
41. Effectiveness of Transactional Analysis Intervention on Treatment Acceptance, Primary Maladaptive Schema, and Interpersonal Problems in Patients Under Methadone Maintenance Treatment, Journal of Substance Use (2022)
42. The Effect of the Blockage of the Receptors of Glutamate N-Methyl-D-Aspartate (Nmda) in Prefrontal Cortex on Morphine Tendency in Male Rat, Journal of Isfahan Medical School (2016)
43. Electrical Stimulation Mpfc Affects Morphine Addiction by Changing Glutamate Concentration in the Ventral Tegmental Area, Metabolic Brain Disease (2019)
44. Retention Rate in Methadone Maintenance Treatment and Factors Associated Among Referred Patients From the Compulsory Residential Centers Compared to Voluntary Patients, Frontiers in Psychiatry (2023)
45. The Effect of Add-On Buprenorphine to Matrix Program in Reduction of Craving and Relapse Among People With Methamphetamine Use Disorder: A Randomized Controlled Trial, Journal of Clinical Psychopharmacology (2021)
46. Sustained-Release Methylphenidate in Methamphetamine Dependence Treatment: A Double-Blind and Placebo-Controlled Trial, DARU, Journal of Pharmaceutical Sciences (2015)
47. The Efficacy of N-Acetylcysteine in the Treatment of Methamphetamine Dependence: A Double-Blind Controlled, Crossover Study, Archives of Iranian Medicine (2015)
48. The Effect of Sustainable Low-Dose Sildenafil and Cognitive-Behavioral Training on Sexual Function in Methadone-Treated Men–A Randomized Controlled Trial, Journal of Addictive Diseases (2024)
49. Effects of Opium Addiction on Vascular Endothelium, Journal of Isfahan Medical School (2013)
50. Impact of Preemptive Methadone or Paracetamol in Controlling Pain After Lower Abdomen Surgery Under General Anesthesia, Journal of Isfahan Medical School (2018)