Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Crosstalk Between Coronary Artery Bypass Grafting and Mirnas Publisher



Torabi SM2 ; Masoumi S3 ; Poudineh M4 ; Poudineh S4 ; Rabori VS5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine (Clinical Department), Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Cardiovascular Research Center, Tabriz University of Medical Science, Tabriz, Iran
  4. 4. School of Medicine, Mashhad Azad University, Mashhad, Iran
  5. 5. Seyed-Al-Shohada Cardiology Hospital, Urmia University of Medical Sciences, Urmia, Iran

Source: Biology Bulletin Published:2023


Abstract

Abstract: MiRNAs, which are small noncoding RNA molecules that regulate over 60% of genes, modulate gene expression. MiRNAs have been implicated in numerous cardiovascular disorders, including ischemic heart disease, left ventricular hypertrophy, hypertension, and heart failure. Additionally, changes in miRNA expression have been observed following coronary artery bypass grafting (CABG) surgery and have been suggested as a potential means of predicting surgical outcomes. CABG is a surgical intervention that addresses complicated coronary artery stenosis by bypassing atherosclerotic lesions using arterial or venous grafts. CABG is associated with surgical problems like perioperative myocardial infarction, atrial fibrillation, reperfusion injury, and graft failure despite its great long-term survival and low perioperative mortality. At present, there are no reliable diagnostic or prognostic methods for predicting outcomes after CABG. However, changes in miRNA expression levels during the perioperative period could be utilized to improve the diagnosis of post-CABG complications and stratify risk in patients with CABG. This article discusses the alterations in expression of miRNA subtypes and explores the potential prognostic and diagnostic value of miRNAs in CABG patients. © 2023, Pleiades Publishing, Inc.
Related Docs
View other Related Docs
1. The Potential for Circulating Micrornas in the Diagnosis of Myocardial Infarction: A Novel Approach to Disease Diagnosis and Treatment, Current Pharmaceutical Design (2016)
2. The Role of Serum Levels of Microrna-21 and Matrix Metalloproteinase-9 in Patients With Acute Coronary Syndrome, Molecular and Cellular Biochemistry (2016)
3. Association of Serum Microrna-21 Levels With Visfatin, Inflammation, and Acute Coronary Syndromes, Heart and Vessels (2017)
4. Transcatheter Ventricular Septal Rupture Closure: A Challenging Case of Basal Inferoseptal Aneurysm and Rupture; [Transkateter Ventrikuler Septal Ruptur Kapanmasi: Zorlu Bir Bazal Inferoseptal Anevrizma Ve Ruptur Olgusu], Turk Kardiyoloji Dernegi Arsivi (2021)
5. The Value of Epicardial Adipose Tissue Thickness for Outcome Prediction of Patients Undergoing Coronary Artery Bypass Grafting Surgery, Journal of Research in Medical Sciences (2019)
6. Circulating Micrornas As Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives, Current Medicinal Chemistry (2016)
7. Role of Long Noncoding Rnas in Pathological Cardiac Remodeling After Myocardial Infarction: An Emerging Insight Into Molecular Mechanisms and Therapeutic Potential, Biomedicine and Pharmacotherapy (2024)
8. Incidence of Atrioventricular Block After Isolated Coronary Artery Bypass Grafting: A Systematic Review and Pooled-Analysis, Frontiers in Cardiovascular Medicine (2023)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (3)
Nizal Sarrafzadegan (2)
Other Related Docs
9. Relationship Between Complete Revascularization and Survival After Post-Infarction Ventricular Septal Rupture, ARYA Atherosclerosis (2023)
10. Evaluation of Microrna Expression Pattern (Mir-28, Mir-181A, Mir-34A, and Mir-31) in Patients With Covid-19 Admitted to Icu and Diabetic Covid-19 Patients, Intervirology (2023)
11. Microrna-155 and Exosomal Microrna-155: Small Pieces in the Cardiovascular Diseases Puzzle, Pathology Research and Practice (2024)
12. Comparison of Survival Rate and Complications of Percutaneous Coronary Intervention, Coronary Artery Bypass Graft, and Medical Treatment in Patients With Left Main And/Or Three Vessel Diseases, ARYA Atherosclerosis (2020)
13. Epigenetic Regulation in Myocardial Infarction: Non-Coding Rnas and Exosomal Non-Coding Rnas, Frontiers in Cardiovascular Medicine (2022)
14. Micrornas As the Actors in the Atherosclerosis Scenario, Journal of Physiology and Biochemistry (2020)
15. Apoptosis and Myocardial Infarction: Role of Ncrnas and Exosomal Ncrnas, Epigenomics (2023)
16. A Meta-Analysis of Microrna Expression Profiling Studies in Heart Failure, Heart Failure Reviews (2021)
17. Can Mir-503 Be Used As a Marker in Diabetic Patients With Ischemic Stroke?, BMC Endocrine Disorders (2019)
18. Medical Therapy Versus Percutaneous Coronary Intervention or Coronary Artery Bypass Graft in Stable Coronary Artery Disease; a Systematic Review and Meta-Analysis of Randomized Clinical Trials, ARYA Atherosclerosis (2022)
19. Role of Micrornas in Pulmonary Hypertension, Horizons in World Cardiovascular Research (2022)
20. Mir-939, As an Important Regulator in Various Cancers Pathogenesis, Has Diagnostic, Prognostic, and Therapeutic Values: A Review, Journal of the Egyptian National Cancer Institute (2024)
21. The Relation Between the Mean Time Interval of Opening of Aortic Cross Clamp to the End of Cardiopulmonary Bypass With Surgical Results of Patient After Coronary Artery Bypass Grafting Surgery, Journal of Isfahan Medical School (2017)
22. Modulations of Obesity-Related Micrornas After Exercise Intervention: A Systematic Review and Bioinformatics Analysis, Molecular Biology Reports (2021)
23. Evaluation of Mir-146A As a Potential Biomarker for Diagnosis of Cardiotoxicity Induced by Chemotherapy in Patients With Breast Cancer, Journal of Research in Medical Sciences (2025)
24. Comparative Study of Clinical Outcomes of Methylprednisolone and Dexamethasone in Prime Solution During Cardiopulmonary Pump After Coronary Artery Bypass Grafting, Journal of Cellular and Molecular Anesthesia (2021)
25. Evaluation of Expression Level of Mir-3135B-5P in Blood Samples of Breast Cancer Patients Experiencing Chemotherapy-Induced Cardiotoxicity, Indian Journal of Clinical Biochemistry (2023)
26. Detrimental Predictive Effect of Metabolic Syndrome on Postoperative Complications in Patients Who Undergoing Coronary Artery Bypass Grafting, Acta Biomedica (2015)
27. Predictive Value of P-Wave Duration and Dispersion in Post Coronary Artery Bypass Surgery Atrial Fibrillation, ARYA Atherosclerosis (2012)
28. Modulation of Micrornas by Aspirin in Cardiovascular Disease, Trends in Cardiovascular Medicine (2020)
29. Which Technique Is Suitable for Management of Acute Myocardial Infarction Following Coronary Artery Bypass Surgery, Rescue Percutaneous Coronary Intervention or Open Heart Surgery? a Case-Series Study, Acta Biomedica (2014)