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The Seroprevalence and Seropositivity of Sars-Cov-2 Among Healthcare Workers During the Third Pandemic Wave Publisher



Vaezi A1 ; Fakhim H2 ; Abbasi S3 ; Masoudi S1 ; Rizi MH2 ; Haghjooy Javanmard S4
Authors
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Authors Affiliations
  1. 1. Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  2. 2. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  3. 3. Anesthesiology and Critical Care Research Center, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  4. 4. Department of Physiology, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran

Source: Antibodies Published:2023


Abstract

Background: Due to the unclear protective role of produced antibodies and the need for seroepidemiologic studies, we surveyed the COVID-19 seroprevalence among healthcare professionals who had direct or indirect contact with COVID-19 patients. Methods: From 19 October 2020 to 17 February 2021, 300 healthcare workers were enrolled and tested for serum antibodies in this prospective cohort study. Demographic information, risk factors, and infection history were collected. Anti- SARS-CoV-2 IgG and IgM antibody titers were determined to estimate the seroconversion rate. Results: During the first and second phases of the study, the positive seroconversion rates were 31.7 and 26.6%, respectively. In seronegative individuals, sixteen (10.6%) new cases of COVID-19 and five (6.3%) reinfections were identified. Among those with a positive antibody level, forty-one (36.9%) healthcare workers reported no symptoms in the preceding months. There was no association between occupational exposure and an increased probability of seroconversion. Conclusions: The seropositivity rate and the rate of asymptomatic individuals with seroconversion was remarkable and could be an indicator of a high infection rate among healthcare workers. © 2022 by the authors.
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