Multiple Myeloma Presenting As Acute Tubulointerstitial Nephritis and Normal Serum Protein Electrophoresis Pubmed



Momeni A¹ ; Hajigholami A¹ ; Nasri H²
Source: Iranian Journal of Kidney Diseases Published:2012

Abstract

Multiple myeloma is uncommon in individuals younger than 40 years. Renal involvement is common in this disease, but acute tubulointerstitial nephritis is very rare. In 20% of patients, only the light chain is produced and serum protein electrophoresis is normal; however, in urine protein electrophoresis of these patients, the M spike is present. We reported a case of multiple myeloma in a 39-year-old man with acute tubulointerstitial nephritis. Serum protein electrophoresis was normal and there was no bone lytic lesion. Remission of multiple myeloma was achieved after treatment with thalidomide and dexamethasone; however, kidney failure was not improved and the patient was maintained on hemodialysis.