The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study

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The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study Publisher

Soflaei SS¹ ; Baktashian M^{2, 3} ; Saberikarimian M¹ ; Esmaily H^{4, 5} ; Moohebati M⁶ ; Ebrahimi M⁶ ; Gholoobi A^{7, 8} ; Hashemi SM⁹ ; Ghazizadeh H¹ ; Ferns GA¹⁰ ; Salehi M¹¹ ; Pasdar A^{8, 12} ; Ghayourmobarhan M^{1, 7}

Show Affiliations

1. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
2. National Center for Health Insurance Reseasrch, Tehran, Iran
3. Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
4. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5. Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
6. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7. Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
9. Department of Cardiology, Chamran Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, United Kingdom
11. Department of genetics, Faculty of medicine and genetics laboratory AL Zahra hospital, Isfahan University of medicine, Isfahan, Iran
12. Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom

Source: Gene Reports Published:2023

Abstract

Background: PON1 polymorphisms and enzyme activity have been reported to be associated with cardiovascular disease (CVD). The aim of current study was to assess the association of these PON1 SNPs and serum enzyme activity and with restenosis following coronary artery stenting. Methods: A total of 306 unrelated Iranian patients with history of coronary stent implantation who underwent elective re-angiography were enrolled in the current study. Three single nucleotide polymorphisms (SNPs) of PON1 gene were genotyped. We used a double ARMS PCR method for genotyping at the Q192R and L55M loci, and PCR-RFLP method for C-108 T. Serum mRNA expression of PON1 was determined using SYBER green method and Roche LightCycler. Results: There were 104 patients considered as in-stent restenosis (ISR) (mean age: 60.55 ± 8.60 years), and 202 individuals as non ISR (NISR) (mean age: 61.94 ± 9.18 years). There were no significant difference between paraoxonase and arylestrase actvities of paraoxonase 1 enzyme. Furthermore, there were no significant differences in the distribution of genotypes of PON1 polymorphism with ISR compared to the control group. The AAC haplotype was the most frequent haplotype in our population study, and haplotypes were not associated with ISR occurrence. The difference between serum mRNA expression of PON1 was not significant between ISR and NISR groups. Conclusions: According to our finding it seems that paraoxonase 1 activities, the most important polymorphisms of PON1 including Q192R, L55M and C-108 T and serum mRNA expression of PON1 are not beneficial markers for ISR diagnosis. © 2023 Elsevier Inc.

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Style	Citing Format
MLA	Soflaei SS, et al.. "The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study." Gene Reports, vol. 31, no. , 2023, pp. -.
APA	Soflaei SS, Baktashian M, Saberikarimian M, Esmaily H, Moohebati M, Ebrahimi M, Gholoobi A, Hashemi SM, Ghazizadeh H, Ferns GA, Salehi M, Pasdar A, Ghayourmobarhan M (2023). The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study. Gene Reports, 31(), -.
Chicago	Soflaei SS, Baktashian M, Saberikarimian M, Esmaily H, Moohebati M, Ebrahimi M, Gholoobi A, et al.. "The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study." Gene Reports 31, no. (2023): -.
Harvard	Soflaei SS et al. (2023) 'The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study', Gene Reports, 31(), pp. -.
Vancouver	Soflaei SS, Baktashian M, Saberikarimian M, Esmaily H, Moohebati M, Ebrahimi M, et al.. The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study. Gene Reports. 2023;31():-.
BibTex	@article{ author = {Soflaei SS and Baktashian M and Saberikarimian M and Esmaily H and Moohebati M and Ebrahimi M and Gholoobi A and Hashemi SM and Ghazizadeh H and Ferns GA and Salehi M and Pasdar A and Ghayourmobarhan M}, title = {The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study}, journal = {Gene Reports}, volume = {31}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Soflaei SS AU - Baktashian M AU - Saberikarimian M AU - Esmaily H AU - Moohebati M AU - Ebrahimi M AU - Gholoobi A AU - Hashemi SM AU - Ghazizadeh H AU - Ferns GA AU - Salehi M AU - Pasdar A AU - Ghayourmobarhan M TI - The Association of Paraoxonase 1 Activities, Serum Mrna Expression and Polymorphisms With In-Stent Coronary Restenosis; a Case-Control Study JO - Gene Reports VL - 31 IS - SP - EP - PY - 2023 ER -

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