Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease

Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease Publisher Pubmed

Soflaei SS¹ ; Baktashian M¹ ; Moghaddam KH² ; Saberikarimian M³ ; Kosari N¹ ; Hashemi SM⁴ ; Mouhebati M⁵ ; Amini M¹ ; Dehghani M⁵ ; Esmaily H⁶ ; Ebrahimi M⁵ ; Falsoleiman H⁵ ; Nosratitirkani A⁷ ; Sadabadi F¹ Show All Authors

Soflaei SS¹
Baktashian M¹
Moghaddam KH²
Saberikarimian M³
Kosari N¹
Hashemi SM⁴
Mouhebati M⁵
Amini M¹
Dehghani M⁵
Esmaily H⁶
Ebrahimi M⁵
Falsoleiman H⁵
Nosratitirkani A⁷
Sadabadi F¹
Ferns GA⁸
Salehi M⁹
Pasdar A^{1, 10}
Ghayourmobarhan M^{3, 5}

Show Affiliations

1. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
2. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3. Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. Department of Cardiology, Chamran Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6. Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
7. Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, United Kingdom
9. Department of genetics, Faculty of medicine and genetics laboratory AL Zahra hospital, Isfahan University of Medicine, Isfahan, Iran
10. Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom

Source: Arquivos Brasileiros de Cardiologia Published:2022

Abstract

Background: It has been shown that increased serum PON1 levels are protective against several disorders. Several single nucleotide polymorphisms (SNPs) of the PON1 gene have been reported to be associated with serum enzyme protein levels and activity. Objective: To investigate the association of SNPs of PON1 and serum paraoxonase activity with coronary artery disease (CAD). Methods: A total of 601 unrelated patients who underwent coronary angiography including those who had >50% stenosis (N=266) and those with <30% stenosis (N=335) were studied. The Paraoxonase gene rs662 and rs840560 SNPs were determined using the ARMS-PCR method and the rs705379 SNP was genotyped using PCR-RFLP analysis. Serum paraoxonase activity was measured using paraoxon as a substrate. A p value of p<0.05 was considered as significant. Results: Serum paraoxonase activity was not significantly different between the study groups. After adjustment for age, sex, hypertension, diabetes mellitus and dyslipidemia, the GG genotype and co-dominant model of rs662 was positively associated with a positive angiogram (respectively, OR=2.424, 95%CI [1.123-5.233], p<0.05, OR=1.663, 95%CI [1.086-2.547]). Serum paraoxonase activity was significantly higher in the G allele and GG variant of rs662, A allele and AA variant of rs854560 and C allele and CC variant of rs705379. The haplotype analysis has shown that the ATC haplotype was significantly more prevalent among the angiogram negative group. The analysis between groups indicated that the A allele of rs662 was significantly associated with lower paraoxonase activity in the positive angiogram group (p=0.019). The presence of the G allele of the rs662 single nucleotide polymorphism is independently associated to increased risk of CAD. © 2022, Sociedade Brasileira de Cardiologia. All rights reserved.

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Masoumeh Sadeghi (3)

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Style	Citing Format
MLA	Soflaei SS, et al.. "Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease." Arquivos Brasileiros de Cardiologia, vol. 119, no. 4, 2022, pp. 593-601.
APA	Soflaei SS, Baktashian M, Moghaddam KH, Saberikarimian M, Kosari N, Hashemi SM, Mouhebati M, Amini M, Dehghani M, Esmaily H, Ebrahimi M, Falsoleiman H, Nosratitirkani A, Sadabadi F, Ferns GA, Salehi M, Pasdar A, Ghayourmobarhan M (2022). Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease. Arquivos Brasileiros de Cardiologia, 119(4), 593-601.
Chicago	Soflaei SS, Baktashian M, Moghaddam KH, Saberikarimian M, Kosari N, Hashemi SM, Mouhebati M, et al.. "Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease." Arquivos Brasileiros de Cardiologia 119, no. 4 (2022): 593-601.
Harvard	Soflaei SS et al. (2022) 'Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease', Arquivos Brasileiros de Cardiologia, 119(4), pp. 593-601.
Vancouver	Soflaei SS, Baktashian M, Moghaddam KH, Saberikarimian M, Kosari N, Hashemi SM, et al.. Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease. Arquivos Brasileiros de Cardiologia. 2022;119(4):593-601.
BibTex	@article{ author = {Soflaei SS and Baktashian M and Moghaddam KH and Saberikarimian M and Kosari N and Hashemi SM and Mouhebati M and Amini M and Dehghani M and Esmaily H and Ebrahimi M and Falsoleiman H and Nosratitirkani A and Sadabadi F and Ferns GA and Salehi M and Pasdar A and Ghayourmobarhan M}, title = {Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease}, journal = {Arquivos Brasileiros de Cardiologia}, volume = {119}, number = {4}, pages = {593-601}, year = {2022} }
RIS	TY - JOUR AU - Soflaei SS AU - Baktashian M AU - Moghaddam KH AU - Saberikarimian M AU - Kosari N AU - Hashemi SM AU - Mouhebati M AU - Amini M AU - Dehghani M AU - Esmaily H AU - Ebrahimi M AU - Falsoleiman H AU - Nosratitirkani A AU - Sadabadi F AU - Ferns GA AU - Salehi M AU - Pasdar A AU - Ghayourmobarhan M TI - Association of Paraoxonase-1 Genotype and Phenotype With Angiogram Positive Coronary Artery Disease JO - Arquivos Brasileiros de Cardiologia VL - 119 IS - 4 SP - 593 EP - 601 PY - 2022 ER -

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