Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer

Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer Publisher Pubmed

Ansari N¹ ; Shahrabi S² ; Khosravi A³ ; Shirzad R⁴ ; Rezaeean H⁴

Show Affiliations

1. Research Center of Thalassemia and Hemoglobinopathy, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3. Department of Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
4. Isfahan Bone Metabolic Disorders Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Lab Medicine Published:2019

Abstract

Breast cancer (BC) is one of the most common cancers among women; genetic mutations reflect the development of this disease. Mutations in cell signaling factors can be the main cause of BC development. In this study, we focused on mutations in checkpoint kinase 2 (CHEK2) and their impact as a prognostic factor in the pathogenesis of BC. CHEK2 is controlled in cell signaling pathways through the influence of upstream genes. Also, several downstream genes are regulated by CHEK2. In addition, mutations in CHEK2 lead to resistance of BC cells to chemotherapy and metastasis of cancer cells to other parts of the body. Finally, detection of mutations in CHEK2 can be used as a prognostic factor for patient response to treatment and for targeting downstream molecules of CHEK2 that are involved in the proliferation of breast tumor cells. Mutations such as c.1100delC and I157T can distinguish which patients are susceptible to metastasis. © 2019 American Society for Clinical Pathology 2019. All rights reserved.

Related Docs

View other Related Docs

1. Glis2 and Ccnd1 Expression Levels in Breast Cancer Patients, Breast Disease (2023)

2. A Novel Carcinogenic Pi3kα Mutation Suggesting the Role of Helical Domain in Transmitting Nsh2 Regulatory Signals to Kinase Domain, Life Sciences (2021)

3. The Role of P130cas/Bcar1 Adaptor Protein in the Pathogenesis of Cardiovascular Diseases: A Literature Review, American Heart Journal Plus: Cardiology Research and Practice (2024)

4. Mini Review: The Fda-Approved Prescription Drugs That Target the Mapk Signaling Pathway in Women With Breast Cancer, Breast Disease (2021)

5. A2b Adenosine Receptor Agonist Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Stem Cells Via Erk1/2 Phosphorylation, Cellular Oncology (2018)

6. An Immunohistochemistry Study of Tissue Bcl-2 Expression and Its Serum Levels in Breast Cancer Patients, Annals of the New York Academy of Sciences (2008)

7. Association Between the Lengths of Gt Dinucleotide Repeat in the Pik3ca Gene With Breast Cancer Risk, Medical Oncology (2014)

8. Therapeutic Potential of Plk1, Kif4a, Cdca5, Ube2c, Cdt1, Ska3, Aurkb, and Pttg1 Genes in Triple-Negative Breast Cancer: Correlating Their Expression With Sensitivity to Gsk 461364 and Ikk 16 Drugs, Biochemical Genetics (2024)

Experts (# of related papers)

View all Related Experts

Seyed Hossein Hejazi (1)

Mahmoud Aghaei (1)

Style	Citing Format
MLA	Ansari N, et al.. "Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer." Lab Medicine, vol. 50, no. 3, 2019, pp. e36-e41.
APA	Ansari N, Shahrabi S, Khosravi A, Shirzad R, Rezaeean H (2019). Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer. Lab Medicine, 50(3), e36-e41.
Chicago	Ansari N, Shahrabi S, Khosravi A, Shirzad R, Rezaeean H. "Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer." Lab Medicine 50, no. 3 (2019): e36-e41.
Harvard	Ansari N et al. (2019) 'Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer', Lab Medicine, 50(3), pp. e36-e41.
Vancouver	Ansari N, Shahrabi S, Khosravi A, Shirzad R, Rezaeean H. Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer. Lab Medicine. 2019;50(3):e36-e41.
BibTex	@article{ author = {Ansari N and Shahrabi S and Khosravi A and Shirzad R and Rezaeean H}, title = {Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer}, journal = {Lab Medicine}, volume = {50}, number = {3}, pages = {e36-e41}, year = {2019} }
RIS	TY - JOUR AU - Ansari N AU - Shahrabi S AU - Khosravi A AU - Shirzad R AU - Rezaeean H TI - Prognostic Significance of Chek2 Mutation in Progression of Breast Cancer JO - Lab Medicine VL - 50 IS - 3 SP - e36 EP - e41 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract