Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients With Cardiovascular Diseases Publisher



Amirkhani F1 ; Namazi G2 ; Hayatmoghadam B1 ; Pourfarzam M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2019


Abstract

Background: Nowadays, coronary artery diseases (CADs) are among the most common diseases in societies. The aim of this study was to study the interplay between cholesterol absorption and synthesis in two groups of Iranian patients with CAD by measuring the markers of cholesterol synthesis and absorption pathways in plasma. Methods: The study population included 128 patients undergoing clinically indicated coronary angiography. Patients were divided into two groups after scoring the severity of their coronary stenosis; the S-stenosis group (patients with CAD, n = 75) had a significant stenosis indicated by coronary angiography, and the second group, N-stenosis (n = 55), had no significant coronary stenosis. Fasting plasma samples were used to measure cholesterol absorption and synthesis markers by gas chromatography-mass spectrometry (GC-MS). Findings: The level of cholesterol absorption markers in patients with coronary artery stenosis was slightly increased compared to patients without coronary artery stenosis, but this change was statistically significant only for cholestanol (P < 0.050). In terms of cholesterol synthesis markers, the results did not show any significant differences between the two groups (P > 0.050 for all). Conclusion: Study of cholesterol synthesis and absorption markers has not been reported in Iranian patients before. This article reports the results of such study for the first time. Considering the high prevalence of CADs and the importance of cholesterol metabolism in pathology of these diseases, the results may be used to understand some underlying mechanisms of development and progression of these diseases, and to manage the patient better. © 2019, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
2. Fatty Acid Composition of Hdl Phospholipids and Coronary Artery Disease, Journal of Clinical Lipidology (2009)
3. Is Friedewald Formula a Good Estimation for Low Density Lipoprotein Level in Iranian Population?, Journal of Research in Medical Sciences (2012)
4. Investigation of Membrane Fatty Acid Profiles in Erythrocytes of Patients With Stable Coronary Artery Disease, Journal of Clinical Lipidology (2016)
5. Effects of Dietary Supplementation With Ghee, Hydrogenated Oil, or Olive Oil on Lipid Profile and Fatty Streak Formation in Rabbits, ARYA Atherosclerosis (2012)
6. Risk Factors for Coronary Artery Disease in Isfahan, Iran, European Journal of Public Health (1999)
7. Comparison of Equations for the Calculation of Ldl-Cholesterol in Familial Hypercholesterolemia: Data From Iranian Registry, Turk Kardiyoloji Dernegi Arsivi (2022)
8. Association Between Severity of Coronary Disease and Apolipoproteins a and B, Iranian Journal of Endocrinology and Metabolism (2011)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (37)
Masoumeh Sadeghi (28)
Other Related Docs
9. Association of High Level of Hs-Crp With In-Stent Restenosis: A Case-Control Study, Cardiovascular Revascularization Medicine (2019)
10. The Effects of Olive Oil and Cholesterol Enriched Diets on Aortic Fatty Streak Development and Lipid Peroxidation in Rabbits, Nutrition and Health (2022)
11. Enhanced Plasma Level of Lipid Peroxidation in Iranians Could Be Improved by Antioxidants Supplementation, European Journal of Clinical Nutrition (1997)
12. Correlation of Dyslipidemia With Waist to Height Ratio, Waist Circumference, and Body Mass Index in Iranian Adults, Asia Pacific Journal of Clinical Nutrition (2007)
13. Prognostic Value of Coronary Artery Calcium Score for Determination of Presence and Severity of Coronary Artery Disease, Polish Journal of Radiology (2017)
14. Uric Acid: A Risk Factor for Coronary Atherosclerosis?, Cardiovascular Journal of South Africa (2007)
15. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
16. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
17. The Five-Year Trend of Coronary Artery Diseases Based on Angiography Results in Central Part of Iran, Iranian Heart Journal (2012)
18. Association of Whole and Refined Grains Food Consumption With Coronary Artery Disease in a Multi-Center, Case-Control Study of Iranian Adults: Iran Premature Coronary Artery Disease (Ipad), Nutrition, Metabolism and Cardiovascular Diseases (2025)
19. Is Subcutaneous Fat Tissue Associated With Coronary Artery Disease?, Iranian Journal of Endocrinology and Metabolism (2012)
20. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
21. Comparison Common Equations for Ldl-C Calculation With Direct Assay and Developing a Novel Formula in Iranian Children and Adolescents: The Caspian V Study, Lipids in Health and Disease (2020)
22. The Association Between Glycemic Index, Glycemic Load and Total Carbohydrate Intake and Risk of Premature Coronary Artery Disease: Iran Premature Coronary Artery Disease Study (Ipad) - a Case-Control Study, Nutrition, Metabolism and Cardiovascular Diseases (2024)
23. Lipid Lowering by Hydroalcoholic Extracts of Amaranthus Caudatus L. Induces Regression of Rabbits Atherosclerotic Lesions, Lipids in Health and Disease (2011)
24. Diagnostic Performance of 64-Row Coronary Ct Angiography in Detecting Significant Stenosis As Compared With Conventional Invasive Coronary Angiography, ARYA Atherosclerosis (2013)
25. Effect of Ascorbic Acid on the Right and Left Coronary Arteries of Male Rabbits Fed With High-Cholesterol Diet, ARYA Atherosclerosis (2007)
26. The Effect of Hydroalcoholic Extract of Dorema Aucheri on Cd40 Protein Expression in Thoracic Aorta of Male White Rabbits Fed With Hypercholesterolemic Diet, Journal of Isfahan Medical School (2012)
27. Does Lipoprotein (A) Level Have a Predictive Value in Restenosis After Coronary Stenting?, International Journal of Preventive Medicine (2011)
28. Evaluation of Relationship Between Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients, ARYA Atherosclerosis (2014)
29. Prevalence of Total Cholesterol in Iran: Systematic Review and Meta-Analysis, Journal of Mazandaran University of Medical Sciences (2015)
30. Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?, Acta Medica Iranica (2008)
31. The Effect of Contrast Dye Injection and Balloon Inflation on Qtc and Qtc Dispersion in 12 Leads Surface Ekg During Ptca, ARYA Atherosclerosis (2011)
32. Assessment of Metabolic Risk Factors and Heart-Healthy Lifestyle in Atherosclerotic Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention After a 6-Month Follow-Up, Advanced Biomedical Research (2022)
33. Effects of Cardamom Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Phytotherapy Research (2020)
34. The Relationship Between Nut Consumption and Premature Coronary Artery Disease in a Representative Sample of Iranians: Iran-Premature Coronary Artery Disease (Ipad) Study, Public Health Nutrition (2023)
35. Coronary Artery Stenosis and Associations With Indicators of Anthropometric and Diet in Patients Undergoing Coronary Angiography, Journal of Diabetes and Metabolic Disorders (2018)
36. Low Levels of High-Density Lipoprotein Cholesterol Do Not Predict the Incidence of Type 2 Diabetes in an Iranian High-Risk Population: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2016)
37. Effect of Cardiac Rehabilitation on Lipid Profile, Journal of Association of Physicians of India (2003)
38. Epicardial Fat Thickness and Severity of Coronary Heart Disease in Patients With Diabetes Mellitus Type Ii, ARYA Atherosclerosis (2018)
39. Aspirin Resistance Status As Determined by Urinary Thromboxane B 2 (Txb2) Level in Patients With Ischemic Heart Disease and Its Relationship With Severity of Coronary Artery Disease, Journal of Isfahan Medical School (2011)
40. Is Lp(A), As Predictor of Severity of Coronary Artery Disease?, Journal of Isfahan Medical School (2009)
41. Ldl Fatty Acids Composition As a Risk Biomarker of Cardiovascular Disease, Artery Research (2017)
42. Increased Membrane Lipid Peroxidation and Decreased Na+/K+-Atpase Activity in Erythrocytes of Patients With Stable Coronary Artery Disease, Coronary Artery Disease (2015)
43. A Novel Inflammatory Signaling Pathway in Patients With Slow Coronary Flow: Nf-Κb/Il-1Β/Nitric Oxide, Cytokine (2021)
44. Dietary Patterns in Relation to Lipid Profiles Among Iranian Adults, Journal of Cardiovascular and Thoracic Research (2019)
45. Study of Saturated Fatty Acids in Different Traditional Foods Distributed in Isfahan, Iran, Journal of Health System Research (2020)
46. Correlation of Echocardiographic Epicardial Fat Thickness With Severity of Coronary Artery Disease-An Observational Study; [Koroner Arter Hastaliginin Siddeti Ile Ekokardiyografik Epikardiyal Yag Kalinliginin Iliskisi-Gozlemsel Bir Calisma], Anadolu Kardiyoloji Dergisi (2012)
47. Association Between the Platelet-To-Lymphocyte Ratio and the No-Reflow Phenomenon and Thrombolysis in Myocardial Infarction Flow 3 After Primary Percutaneous Coronary Intervention in Patients With St-Segment Elevation Myocardial Infarction, Iranian Heart Journal (2017)
48. Interleukin-6 and E-Selectin in Acute Coronary Syndromes and Stable Angina Pectoris: A Comparative Study, Herz (2012)
49. Effects of Amaranthus Caudatus L. Extract and Lovastatin on Atherosclerosis in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2010)
50. Correlation Between Body Fat Distribution, Plasma Lipids and Apolipoproteins With the Severity of Coronary Involvement in Patients With Stable Angina, ARYA Atherosclerosis (2011)