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A Novel Non-Enzymatic Biosensor Based on Ti-Metallic Glass Thin Film: The Blood Glucose Oxidation Approach Publisher



Sarafbidabad M1 ; Jazi H1 ; Rafienia M2
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  2. 2. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Medical Signals and Sensors Published:2020


Abstract

Background: Material selection is a key issue for the fabrication of non-enzymatic electrode in glucose biosensors. Metallic glass (MG) as an advanced innovative material can provides many basic structural requirements of electrodes. A novel non-enzymatic biosensor based on Ti57Cu28{Zr0.95-Hf0.05}XSi15-XMG (Ti-MG) thin film was introduced for glucose oxidation. Methods: The Ti-MG thin film was deposited on the carbon substrate of screen-printed carbon electrode (SPCE), and the Ti-MG modified SPCE was fabricated as Ti-MG/SPCE. The morphology and structure of the Ti-MG thin film were characterized by field emission scanning electron microscope and X-ray diffraction. Electrochemical evaluations were studied by electrochemical impedance spectroscopy and cyclic voltammetry. Results: The Ti-MG was sputtered on the carbon substrate in the form of a porous spongy thin film with 285 nm thickness and nanoparticles with average diameter size of 110 nm. The Ti-MG/SPCE showed low charge transfer resistance to the electron transfer and high electrocatalytic activity toward the oxidation of glucose in PBS (pH = 7.4) solution. This biosensor exhibited good analytical performance with a linear range from 2 to 8 mM glucose and sensitivity of 0.017 μA mM-1. Conclusion: The experimental results indicate that Ti-MG thin film has a high ability to electron transfer and glucose oxidation for the development of non-enzymatic glucose biosensors. © 2020 Isfahan University of Medical Sciences(IUMS). All rights reserved.
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