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The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy Publisher Pubmed



Behnam M1 ; Motamedzadeh A2 ; Aalinezhad M3 ; Dadgostar E4, 5 ; Rashidi Noshabad FZ1 ; Pourfridoni M6 ; Raei M7 ; Mirzaei H8 ; Aschner M9 ; Tamtaji OR10, 11
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran
  7. 7. Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran
  8. 8. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  10. 10. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Molecular Biology Reports Published:2022


Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.
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