Exploring the Effect of Administering Three Different Doses of Dexmedetomidine As an Adjuvant to Lidocaine in Regional Intravenous Anesthesia for Patients Publisher



M Safavi MOHAMADREZA ; A Honarmand AZIM ; B Nazemroaya BEHZAD ; M Jahandideh MOHSEN
Source: Archives of Anesthesiology and Critical Care Published:2025

Abstract

Background: This study aimed to determine the effect of adding low doses of dexmedetomidine as an adjuvant to lidocaine in regional intravenous anesthesia in patients receiving surgery. Methods: In the present clinical trial, 120 patients' candidates for upper extremity orthopedic surgery with regional venous anesthesia in 4 groups of 30 people distributed in groups respectively 0.6, 0.5 and 0.4 micrograms/kg of dexmedetomidine plus 0.5 lidocaine were injected and in the fourth group, an equal volume of normal saline was administrated. Patients were examined and compared before drug injection and 1, 5, 10, 15, 30, 45 and 60 minutes after drug injection in terms of time of onset and recovery of sensory and motor block, hemodynamic parameters, postoperative pain intensity and analgesic consumption. Results: The average pain intensity during the research in the four dexmedetomidine groups was 0.6, 0.5, 0.4 and the control group, respectively, 2.12 ± 1.33, 2.82 ± 0.76, 2.26 ± 2.3, and 4.4 ± 1.5, and the difference between the groups was significant (>0.001). P). In the two-by-two analysis of the groups, the average pain intensity was significant between the two groups: dexmedetomidine 0.6 and control (P<0.001), dexmedetomidine 0.5 and control (P=0.003), and dexmedetomidine 0.4 and control (P<0.001). Conclusion: Using a dose of 0.6 micrograms/kg of dexmethomidine along with lidocaine leads to a decrease in the severity of the postoperative period, a decrease in the need for painkillers, and also an increase in the time of postoperative pain relief in patients. © 2025 Elsevier B.V., All rights reserved.