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Residual Goiter in Semirom; Iodine Status and Thiocyanate Overload Do Not Play a Role Publisher Pubmed



Keshteli AH1, 2 ; Hashemipour M2 ; Amini M2 ; Siavash M2 ; Aminorroaya A2 ; Rezvanian H2 ; Kachuei A2 ; Kelishadi R3
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Authors Affiliations
  1. 1. Medical Students' Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Tropical Pediatrics Published:2009


Abstract

This study was performed to investigate the role of thiocyanate overload in the etiology of endemic goiter in schoolchildren of Semirom, Iran. A total of 1828 schoolchildren were selected by multi-stage random sampling. Urinary iodine concentration (UIC) and urinary thiocyanate (USCN) were measured in a group of these children. The median UIC was 18.5 μg/dl. The mean ± SD of USCN in goitrous and nongoitrous subjects did not differ significantly (0.75 ± 0.78 mg/dl vs. 0.63 ± 0.40 mg/dl; p = 0.30). Finally, we concluded that neither iodine deficiency nor thiocyanate overload contributed to the high prevalence of goiter in Semirom. The role of other goitrogenic factors should be investigated in this region. © The Author [2009]. Published by Oxford University Press. All rights reserved.
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