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Global, Regional, and National Burden of Allergic Disorders and Their Risk Factors in 204 Countries and Territories, From 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher Pubmed



Shin YH1, 2, 11 ; Hwang J3, 4, 12 ; Kwon R5 ; Lee SW6 ; Kim MS7, 8, 13, 14 ; Shin JI9 ; Yon DK5, 10 ; Abate YH15 ; Abbasikangevari M16 ; Abbasikangevari Z16, 17 ; Abdelmasseh M18 ; Abdulah DM19 ; Aboagye RG20 ; Abolhassani H21, 22 Show All Authors
Authors
  1. Shin YH1, 2, 11
  2. Hwang J3, 4, 12
  3. Kwon R5
  4. Lee SW6
  5. Kim MS7, 8, 13, 14
  6. Shin JI9
  7. Yon DK5, 10
  8. Abate YH15
  9. Abbasikangevari M16
  10. Abbasikangevari Z16, 17
  11. Abdelmasseh M18
  12. Abdulah DM19
  13. Aboagye RG20
  14. Abolhassani H21, 22
  15. Abrams EM23, 24
  16. Abtew YD25
  17. Abugharbieh E26
  18. Adane Adane DE27
  19. Adane TD28
  20. Addo IY29, 30
  21. Adha R31
  22. Adibi A32
  23. Sakilah Adnani QE33
  24. Agrawal A34, 35
  25. Ahmad S36
  26. Ahmadi A37, 38
  27. Ahmed A39, 40
  28. Ahmed A39, 40
  29. Alazzam S43
  30. Naji Alhalaiqa FA44, 45
  31. Alif SM46
  32. Alipour V47, 48
  33. Altaany Z49
  34. Altirkawi KA50
  35. Alvisguzman N51, 52
  36. Aly H53
  37. Ansar A54, 55
  38. Arulappan J56
  39. Asgharijafarabadi M57, 58
  40. Ashraf T59
  41. Athari SS60
  42. Atlaw D61
  43. Aujayeb A62
  44. Azadnajafabad S16
  45. Babaei M63, 64
  46. Babamohamadi H65
  47. Badawi A66, 67
  48. Baghcheghi N68
  49. Bagherieh S69
  50. Bajbouj K70
  51. Banach M71, 72
  52. Bardhan M73, 74
  53. Baroneadesi F75
  54. Barrow A76, 77
  55. Bashiri A78
  56. Bayileyegn NS79
  57. Bensenor IM80
  58. Berhie AY81
  59. Beyene KA82, 83
  60. Bhagavathula AS84
  61. Bhardwaj P85, 86
  62. Bhat AN87
  63. Bhojaraja VS88
  64. Bijani A89
  65. Bikov A90, 91
  66. Cai J92
  67. Camargos P93
  68. Car J94, 95
  69. Carr S96
  70. Carugno A97
  71. Chakraborty PA98
  72. Chan JSK99
  73. Charalampous P100
  74. Chashmyazdan M101
  75. Chattu VK102, 103
  76. Kabir Chowdhury MA104, 105
  77. Chu DT106
  78. Corso B107
  79. Cruzmartins N108, 109
  80. Dadras O110, 111
  81. Dai X96, 112
  82. Damiani G113, 114
  83. Dandona L96, 115, 116
  84. Dandona R96, 112, 115
  85. Demeke D117
  86. Demisse B118
  87. Diaz D119, 120
  88. Diress M121
  89. Dongarwar D122
  90. Ekholuenetale M123, 124
  91. Ekundayo TC125
  92. Elhadi M126
  93. Abdou Elmeligy OA127, 128
  94. Esubalew H129
  95. Etaee F130
  96. Etemadimanesh A131
  97. Fagbamigbe AF123, 132
  98. Fakhradiyev IR133
  99. Fatehizadeh A134
  100. Fatima Fatima SA135, 136
  101. Feng X137, 138
  102. Fereidouni M139, 140
  103. Ferreira N141
  104. Fetensa G142
  105. Fischer F143
  106. Foroutan M144, 145
  107. Fukumoto T146
  108. Gaipov A147
  109. Gela YY148
  110. Obsa AG149
  111. Ghadirian F150
  112. Ghamari SH16, 17
  113. Ghozy S151
  114. Gillum RF152, 153
  115. Gizaw AT154
  116. Gizaw ABAB155
  117. Goldust M156
  118. Golechha M157
  119. Goleij P158
  120. Gupta S159
  121. Gupta VK160
  122. Hajmirzaian A161, 162
  123. Halwani R26, 163
  124. Hamidi S164
  125. Hannan MA165, 166
  126. Hasaballah AI167
  127. Hasani H168
  128. Hashi A169
  129. Hassen MB96, 170
  130. Heibati B171
  131. Heidari G172
  132. Heidari M173
  133. Heidariforoozan M174, 175
  134. Holla R176
  135. Horita N177, 178
  136. Hossain MS179
  137. Hussain S180, 181
  138. Hwang BF182
  139. Ilic IM183
  140. Ilic MD184
  141. Irilouzadian R175, 185
  142. Ismail NE186
  143. Ispayeva ZBIZB187
  144. Iwu CCD188
  145. J LM189
  146. Jajarmi M190
  147. Jamshidi E191, 192
  148. Janodia MD193
  149. Jayaram S194
  150. Jebai R195
  151. Jonas JB196, 197
  152. Joseph N198
  153. Kaambwa B199, 200
  154. Kabir Z201
  155. Kaliyadan F202
  156. Kandel H203, 204
  157. Kantar RS205, 206
  158. Karaye IM207
  159. Karimi H208
  160. Kaur H115
  161. Keikavoosiarani L209
  162. Keykhaei M16, 210
  163. Khader YS211
  164. Khajuria H212
  165. Khan IA213
  166. Khan M214
  167. Khan MAB215, 216
  168. Khanal S217
  169. Khatatbeh MM218
  170. Khubchandani J219
  171. Kibret BG220
  172. Kisa A221, 222
  173. Kisa S223
  174. Kolkhir P224, 225
  175. Kompani F226
  176. Koohestani HR227
  177. Korzh O228
  178. Koul PA229
  179. Koyanagi A230, 231
  180. Krishan K232
  181. Kuehni CE233, 234
  182. Kumar GA115
  183. Kurmi OP235, 236
  184. Kutikuppala LVS237
  185. Kuttikkattu A238
  186. Lam J239, 240
  187. Larijani B241
  188. Latief K242, 243
  189. Lauriola P244
  190. Thu Le TT245
  191. Lee YH246
  192. Lenzi J247
  193. Li MC248
  194. Li S46
  195. Ligade VS249
  196. Lim SS96, 112
  197. Liu G250, 251
  198. Liu W92
  199. Liu X252, 253
  200. Lo CH254
  201. Lopes G255
  202. Mahalingam S256
  203. Maharaj SB257, 258
  204. Mahmoud MA259
  205. Majeed A95
  206. Malekpour MR16
  207. Malik AA260, 261
  208. Mallhi TH262
  209. Malta DC263
  210. Mamun AA264
  211. Masoumi SZ265
  212. Maugeri A266
  213. Medina JRC267, 268
  214. Menezes RG269
  215. Mensah GA270, 271
  216. Mentis AFA272
  217. Mestrovic T96, 273
  218. Michalek IM274, 275
  219. Nhat Minh LH276, 277
  220. Mirrakhimov EM278, 279
  221. Misganaw A112, 280
  222. Mishra M281
  223. Mohammed S282, 283
  224. Mokdad AH96, 112
  225. Momtazmanesh S16, 284
  226. Monasta L285
  227. Moniruzzaman M286
  228. Mulugeta T287
  229. Munblit D288, 289
  230. Murillozamora E290, 291
  231. Mustafa G292, 293
  232. Nair TS294
  233. Nangia V295
  234. Swamy SN296
  235. Nassereldine H96
  236. Natto ZS297, 298
  237. Nayak BP212
  238. Nazari J299
  239. Ng TP300, 301
  240. Nguyen DH302
  241. Nguyen VT303
  242. Niazi RK304
  243. Nouraei H305
  244. Nzoputam OJ306, 307
  245. Oancea B308
  246. Obaidur RM309, 310
  247. Okatialiabad H311
  248. Okonji OC312
  249. Okwute PG313, 314
  250. Olagunju AT315, 316
  251. Olufadewa II124, 317
  252. Orru H318, 319
  253. Mahesh PA320
  254. Padubidri JR321
  255. Pandey A115
  256. Pardhan S322
  257. Park EK323
  258. Patel J324, 325
  259. Patil S326, 327
  260. Patthipati VS328, 329
  261. Paudel U330, 331
  262. Pereira M332
  263. Pereira RB333
  264. Petcu IR334
  265. Podder I335
  266. Podder V336, 337
  267. Mohammad AP338
  268. Qattea I339
  269. Rabiee N340, 341
  270. Rahimi M342
  271. Rahman M343
  272. Rahman MA54, 344
  273. Rahmani AM345
  274. Rahmani S16, 175
  275. Rahmanian V346
  276. Rajput P347
  277. Ram P348
  278. Ramasubramani P349
  279. Rao IR350
  280. Rashid AM351
  281. Ratan ZA352, 353
  282. Ravikumar N354
  283. Rawaf S95, 355
  284. Rawal L356
  285. Mohamed Redwan EM357, 358
  286. Regmi AR359
  287. Rezaei N16
  288. Rezaei N16
  289. Rezaei N16
  290. Rezaei S361, 362
  291. Rezaeian M363
  292. Buendia Rodriguez JA364
  293. Roever L365
  294. Romerorodriguez E366
  295. Ronfani L285
  296. Saad AMA367
  297. Saddik B368
  298. Saeed U369, 370
  299. Sagoe D371
  300. Sharifaskari FS372
  301. Sahebkar A373, 374
  302. Sahoo H375
  303. Sajid MR376
  304. Sakshaug JW377, 378
  305. Salahi S379
  306. Salehi S380
  307. Samy AM381, 382
  308. Santricmilicevic MM183, 383
  309. Sarasmita MA384, 385
  310. Sarkhosh M386, 387
  311. Saya GK388
  312. Senthilkumaran S389
  313. Shah H390
  314. Shaikh MA391
  315. Shanawaz M392
  316. Sheikh A393, 394
  317. Shekhar S395
  318. Shigematsu M396
  319. Shobeiri P397, 398
  320. Shorofi SA399, 400
  321. Sibhat MM401
  322. Simpson CR402, 403
  323. Singh JA404, 405
  324. Singh P406
  325. Singh S407
  326. Singh V408
  327. Siraj MS409
  328. Skryabina AA410
  329. Solomon Y411
  330. Song S412
  331. Soshnikov S413, 414
  332. Soyiri IN415
  333. Steiropoulos P416
  334. Szeto MD417
  335. Talaat IM26, 418
  336. Lukenze Tamuzi JJL419, 420
  337. Tan KK421
  338. Tat NY422, 423
  339. Temsah MH50
  340. Terefa DR424, 425
  341. Tesler R426
  342. Thangaraju P427
  343. Vera Ticoalu JH428
  344. Tillawi T429
  345. Ngoc Tran MT430, 431
  346. Tusa BS432
  347. Ullah I433
  348. Ullah S434
  349. Ullah S434
  350. Upadhyay E437
  351. Vahabi SM398
  352. Boven JFM438
  353. Vasankari TJ439, 440
  354. Verras GI441, 442
  355. Vieira RJ443, 444
  356. Violante FS445, 446
  357. Vos T96, 112
  358. Westerman R447
  359. Wickramasinghe ND448
  360. Williams HC449
  361. Yada DY96
  362. Yismaw Y450, 451
  363. Yonemoto N452, 453
  364. Yu C454
  365. Yunusa I455
  366. Zahir M456
  367. Zar HJ457, 458
  368. Zare I459
  369. Zastrozhin MS460, 461
  370. Zeineddine MA462
  371. Zenebe GA463
  372. Zhang ZJ464
  373. Zhao H465
  374. Zoladl M466

Source: Allergy: European Journal of Allergy and Clinical Immunology Published:2023


Abstract

Background: Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio-demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results: In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] total cases of AD globally; age-standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and AD, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age-specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million [95% UI: 2.14–5.60 million] asthma DALYs and 75,377 [95% UI: 40,615–122,841] asthma deaths. Conclusions: Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age-standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high-SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment. © 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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