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Epidemiology, Sociodemographic Factors and Comorbidity for Allergic Rhinitis, Asthma, and Rhinosinusitis Among 15 to 65-Year-Old Iranian Patients Publisher



Nabavizadeh SH1 ; Moghtaderi M1 ; Alyasin S1 ; Esmaeilzadeh H1 ; Teshnizi SH2 ; Jabbariazad F3 ; Barzegaramini M3 ; Momen T4 ; Sadinejad M5 ; Abolnezhadian F6 ; Iranparast S7 ; Namavari N8 ; Houshmand H9 ; Sartipi M10 Show All Authors
Authors
  1. Nabavizadeh SH1
  2. Moghtaderi M1
  3. Alyasin S1
  4. Esmaeilzadeh H1
  5. Teshnizi SH2
  6. Jabbariazad F3
  7. Barzegaramini M3
  8. Momen T4
  9. Sadinejad M5
  10. Abolnezhadian F6
  11. Iranparast S7
  12. Namavari N8
  13. Houshmand H9
  14. Sartipi M10
  15. Safari M11
  16. Eslamian MH11
  17. Darougar S12
  18. Ahmadiafshar A13
  19. Amirsoleymani M14
  20. Fouladvand A15
  21. Ghaffari J16
  22. Bazargan N17
  23. Ebrahimi S17
  24. Sedighi GR18
  25. Mohammadzadeh I19
  26. Araghi M20
  27. Darabi B21
  28. Babaei M1
  29. Alesaadi SJ22
Show Affiliations
Authors Affiliations
  1. 1. Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  3. 3. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Research Institute of Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Allergy and Clinical Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pediatrics, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. University of California San Diego, San Diego, United States
  9. 9. Department of Pediatrics Division of Allergy and Clinical Immunology, Urmia University of Medical Sciences, Urmia, Iran
  10. 10. Health Promotion Research Center, School of Public Health, Zahedan University of Medical Sciences, Zahedan, Iran
  11. 11. Department of Allergy and Clinical Immunology, Hamadan University of Medical Sciences, Hamadan, Iran
  12. 12. Department of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  13. 13. Zanjan Social Determinants of Health Research Center, Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
  14. 14. Student Research Committee, Department of Immunology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  15. 15. Department of Pediatrics, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran
  16. 16. Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  17. 17. Department of Pediatrics, Kerman University of Medical Sciences, Kerman, Iran
  18. 18. Department of Pediatric, Afzalipour Hospital, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  19. 19. Non-Communicable Pediatrics Diseases Research Center, Babol University of Medical Sciences, Babol, Iran
  20. 20. Department of Pediatrics, Dezful University of Medical Sciences, Dezful, Iran
  21. 21. Department of Pediatrics, Ilam University of Medical Sciences, Ilam, Iran
  22. 22. Deputy of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2022


Abstract

Background: It is well established that upper and lower airways are often clumped together when diagnosing and treating a disease. This study was designed to determine the prevalence of upper and lower airway diseases and to assess the effect of sociodemographic factors on the prevalence and the comorbidity of these disorders. Methods: This cross-sectional population-based study included patients with ages ranging between 15 to 65 years, who were referred to allergy outpatient clinics in various provinces of Iran from April to September 2020. A modified global Allergy and Asthma European Network (GA2LEN) screening questionnaire was filled out by local allergists of the 12 selected provinces in Iran. Information about the patients and sociodemographic factors was also recorded. Statistical analysis was done by univariate statistical analyses and multiple logistic regressions in SPSS software Version 26. Results: Out of 4988 recruited patients, 1078 (21.6%) had the symptoms of allergic rhinitis (AR) and 285 (5.7%) met the criteria of asthma. The prevalence of acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) was 21.6 % and 22%, respectively. The highest prevalence of AR and ARS was in Tehran with the arateof of 33.9% each. Asthma was more prevalent in Khuzestan (14.2%) and CRS in Baluchestan (57.5%). Our analysis showed that the patients with asthma were most likely to have other allergic diseases as well— CRS (OR = 4.8; 95% CI, 2.02-5.82), AR (OR= 2.5, 95% CI, 2.10-3), ARS (OR = 1.8; 95% CI, 2.10-3), followed by eczema (OR = 1.4; 95% CI, 1.13-1.67).We found that those individuals with CRS were most likely to have painkiller hypersensitivity (OR= 2.1; 95% CI, 1.21-3.83). Furthermore, smoking has been found more than 1.5 folds in patients with ARS. After adjusting variables, there was no correlation between education, occupation, and ethnicity with the studied diseases. Conclusion: Rhinosinusitis is a common condition among Iranian patients. This study confirmed that inflammation of the upper and lower airways can occur simultaneously. Gender, education, occupation, and ethnicity were found to be irrelevant in the development © Iran University of Medical Sciences
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