Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways

Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways Publisher Pubmed

Lim HF^{1, 2} ; Tan NS² ; Dehghan R^{3, 4} ; Shen M⁵ ; Liew MF^{1, 2} ; Bee SWL⁶ ; Sia YY³ ; Liu J^{2, 3} ; Khor CC^{3, 7} ; Kwok I^{5, 8} ; Ng LG^{5, 8, 9, 10} ; Angeli V¹¹ ; Dorajoo R^{3, 12}

Source: Lung Published:2022

Abstract

Telomere attrition is an established ageing biomarker and shorter peripheral blood leukocyte telomere length has been associated with increased risks of respiratory diseases. However, whether telomere length in disease-relevant sputum immune cells of chronic respiratory disease patients is shortened and which pathways are dysfunctional are not clear. Here we measured telomere length from sputum samples of bronchiectasis and asthmatic subjects and determined that telomere length in sputum of bronchiectasis subjects was significantly shorter (Beta = − 1.167, PAdj = 2.75 × 10−4). We further performed global gene expression analysis and identified genes involved in processes such as NLRP3 inflammasome activation and regulation of adaptive immune cells when bronchiectasis sputum telomere length was shortened. Our study provides insights on dysfunctions related to shortened telomere length in sputum immune cells of bronchiectasis patients. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Rasoul Salehi (2)

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Style	Citing Format
MLA	Lim HF, et al.. "Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways." Lung, vol. 200, no. 3, 2022, pp. 401-407.
APA	Lim HF, Tan NS, Dehghan R, Shen M, Liew MF, Bee SWL, Sia YY, Liu J, Khor CC, Kwok I, Ng LG, Angeli V, Dorajoo R (2022). Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways. Lung, 200(3), 401-407.
Chicago	Lim HF, Tan NS, Dehghan R, Shen M, Liew MF, Bee SWL, Sia YY, et al.. "Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways." Lung 200, no. 3 (2022): 401-407.
Harvard	Lim HF et al. (2022) 'Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways', Lung, 200(3), pp. 401-407.
Vancouver	Lim HF, Tan NS, Dehghan R, Shen M, Liew MF, Bee SWL, et al.. Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways. Lung. 2022;200(3):401-407.
BibTex	@article{ author = {Lim HF and Tan NS and Dehghan R and Shen M and Liew MF and Bee SWL and Sia YY and Liu J and Khor CC and Kwok I and Ng LG and Angeli V and Dorajoo R}, title = {Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways}, journal = {Lung}, volume = {200}, number = {3}, pages = {401-407}, year = {2022} }
RIS	TY - JOUR AU - Lim HF AU - Tan NS AU - Dehghan R AU - Shen M AU - Liew MF AU - Bee SWL AU - Sia YY AU - Liu J AU - Khor CC AU - Kwok I AU - Ng LG AU - Angeli V AU - Dorajoo R TI - Shortened Telomere Length in Sputum Cells of Bronchiectasis Patients Is Associated With Dysfunctional Inflammatory Pathways JO - Lung VL - 200 IS - 3 SP - 401 EP - 407 PY - 2022 ER -

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