Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy

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Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy Publisher Pubmed

Beziat V^{1, 2} ; Rapaport F² ; Hu J³ ; Titeux M¹ ; Bonnet Des Claustres M¹ ; Bourgey M⁴ ; Griffin H⁵ ; Bandet E¹ ; Ma CS^{6, 7} ; Sherkat R⁸ ; Roknizadeh H⁹ ; Louis DM¹⁰ ; Changiashtiani M¹¹ ; Delmonte OM¹² Show All Authors

Beziat V^{1, 2}
Rapaport F²
Hu J³
Titeux M¹
Bonnet Des Claustres M¹
Bourgey M⁴
Griffin H⁵
Bandet E¹
Ma CS^{6, 7}
Sherkat R⁸
Roknizadeh H⁹
Louis DM¹⁰
Changiashtiani M¹¹
Delmonte OM¹²
Fukushima T¹³
Habib T¹⁴
Guennoun A¹⁴
Khan T¹⁴
Bender N¹⁵
Rahman M¹⁴
About F¹
Yang R²
Rao G^{6, 7}
Rouzaud C^{1, 16}
Li J³
Shearer D³
Balogh K³
Al Ali F¹⁴
Ata M¹⁴
Dabiri S¹⁷
Momenilandi M¹⁸
Nammour J¹
Alyanakian MA¹⁶
Leruezville M¹⁶
Guenat D¹⁹
Materna M¹
Marcot L¹
Vladikine N¹
Soret C¹⁹
Vahidnezhad H²⁰
Youssefian L²⁰
Saeidian AH²⁰
Uitto J²⁰
Catherinot E²¹
Navabi SS²²
Zarhrate M¹
Woodley DT²³
Jeljeli M²⁴
Abraham T³
Belkaya S²
Lorenzo L¹
Rosain J^{1, 16}
Bayat M¹⁷
Lanternier F^{1, 16}
Lortholary O^{1, 16}
Zakavi F²⁵
Gros P^{4, 26}
Orth G²⁷
Abel L^{1, 2}
Pretet JL¹⁹
Fraitag S¹⁶
Jouanguy E^{1, 2}
Davis MM²⁸
Tangye SG^{6, 7}
Notarangelo LD¹²
Marr N¹⁴
Waterboer T¹⁵
Langlais D^{4, 26}
Doorbar J⁵
Hovnanian A^{1, 16}
Christensen N³
Bossuyt X¹⁸
Shahrooei M^{18, 22}
Casanova JL^{1, 2, 29}

Source: Cell Published:2021

Abstract

We study a patient with the human papilloma virus (HPV)-2-driven “tree-man” phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity. © 2021 Elsevier Inc.

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Style	Citing Format
MLA	Beziat V, et al.. "Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy." Cell, vol. 184, no. 14, 2021, pp. 3812-3828.e30.
APA	Beziat V, Rapaport F, Hu J, Titeux M, Bonnet Des Claustres M, Bourgey M, Griffin H, Bandet E, Ma CS, Sherkat R, Roknizadeh H, Louis DM, Changiashtiani M, Delmonte OM, Fukushima T, Habib T, Guennoun A, Khan T, Bender N, ... Casanova JL (2021). Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy. Cell, 184(14), 3812-3828.e30.
Chicago	Beziat V, Rapaport F, Hu J, Titeux M, Bonnet Des Claustres M, Bourgey M, Griffin H, et al.. "Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy." Cell 184, no. 14 (2021): 3812-3828.e30.
Harvard	Beziat V et al. (2021) 'Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy', Cell, 184(14), pp. 3812-3828.e30.
Vancouver	Beziat V, Rapaport F, Hu J, Titeux M, Bonnet Des Claustres M, Bourgey M, et al.. Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy. Cell. 2021;184(14):3812-3828.e30.
BibTex	@article{ author = {Beziat V and Rapaport F and Hu J and Titeux M and Bonnet Des Claustres M and Bourgey M and Griffin H and Bandet E and Ma CS and Sherkat R and Roknizadeh H and Louis DM and Changiashtiani M and Delmonte OM and Fukushima T and Habib T and Guennoun A and Khan T and Bender N and Rahman M and About F and Yang R and Rao G and Rouzaud C and Li J and Shearer D and Balogh K and Al Ali F and Ata M and Dabiri S and Momenilandi M and Nammour J and Alyanakian MA and Leruezville M and Guenat D and Materna M and Marcot L and Vladikine N and Soret C and Vahidnezhad H and Youssefian L and Saeidian AH and Uitto J and Catherinot E and Navabi SS and Zarhrate M and Woodley DT and Jeljeli M and Abraham T and Belkaya S and Lorenzo L and Rosain J and Bayat M and Lanternier F and Lortholary O and Zakavi F and Gros P and Orth G and Abel L and Pretet JL and Fraitag S and Jouanguy E and Davis MM and Tangye SG and Notarangelo LD and Marr N and Waterboer T and Langlais D and Doorbar J and Hovnanian A and Christensen N and Bossuyt X and Shahrooei M and Casanova JL}, title = {Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy}, journal = {Cell}, volume = {184}, number = {14}, pages = {3812-3828.e30}, year = {2021} }
RIS	TY - JOUR AU - Beziat V AU - Rapaport F AU - Hu J AU - Titeux M AU - Bonnet Des Claustres M AU - Bourgey M AU - Griffin H AU - Bandet E AU - Ma CS AU - Sherkat R AU - Roknizadeh H AU - Louis DM AU - Changiashtiani M AU - Delmonte OM AU - Fukushima T AU - Habib T AU - Guennoun A AU - Khan T AU - Bender N AU - Rahman M AU - About F AU - Yang R AU - Rao G AU - Rouzaud C AU - Li J AU - Shearer D AU - Balogh K AU - Al Ali F AU - Ata M AU - Dabiri S AU - Momenilandi M AU - Nammour J AU - Alyanakian MA AU - Leruezville M AU - Guenat D AU - Materna M AU - Marcot L AU - Vladikine N AU - Soret C AU - Vahidnezhad H AU - Youssefian L AU - Saeidian AH AU - Uitto J AU - Catherinot E AU - Navabi SS AU - Zarhrate M AU - Woodley DT AU - Jeljeli M AU - Abraham T AU - Belkaya S AU - Lorenzo L AU - Rosain J AU - Bayat M AU - Lanternier F AU - Lortholary O AU - Zakavi F AU - Gros P AU - Orth G AU - Abel L AU - Pretet JL AU - Fraitag S AU - Jouanguy E AU - Davis MM AU - Tangye SG AU - Notarangelo LD AU - Marr N AU - Waterboer T AU - Langlais D AU - Doorbar J AU - Hovnanian A AU - Christensen N AU - Bossuyt X AU - Shahrooei M AU - Casanova JL TI - Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy JO - Cell VL - 184 IS - 14 SP - 3812 EP - 3828.e30 PY - 2021 ER -