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Humans With Inherited T Cell Cd28 Deficiency Are Susceptible to Skin Papillomaviruses But Are Otherwise Healthy Publisher Pubmed



Beziat V1, 2 ; Rapaport F2 ; Hu J3 ; Titeux M1 ; Bonnet Des Claustres M1 ; Bourgey M4 ; Griffin H5 ; Bandet E1 ; Ma CS6, 7 ; Sherkat R8 ; Roknizadeh H9 ; Louis DM10 ; Changiashtiani M11 ; Delmonte OM12 Show All Authors
Authors
  1. Beziat V1, 2
  2. Rapaport F2
  3. Hu J3
  4. Titeux M1
  5. Bonnet Des Claustres M1
  6. Bourgey M4
  7. Griffin H5
  8. Bandet E1
  9. Ma CS6, 7
  10. Sherkat R8
  11. Roknizadeh H9
  12. Louis DM10
  13. Changiashtiani M11
  14. Delmonte OM12
  15. Fukushima T13
  16. Habib T14
  17. Guennoun A14
  18. Khan T14
  19. Bender N15
  20. Rahman M14
  21. About F1
  22. Yang R2
  23. Rao G6, 7
  24. Rouzaud C1, 16
  25. Li J3
  26. Shearer D3
  27. Balogh K3
  28. Al Ali F14
  29. Ata M14
  30. Dabiri S17
  31. Momenilandi M18
  32. Nammour J1
  33. Alyanakian MA16
  34. Leruezville M16
  35. Guenat D19
  36. Materna M1
  37. Marcot L1
  38. Vladikine N1
  39. Soret C19
  40. Vahidnezhad H20
  41. Youssefian L20
  42. Saeidian AH20
  43. Uitto J20
  44. Catherinot E21
  45. Navabi SS22
  46. Zarhrate M1
  47. Woodley DT23
  48. Jeljeli M24
  49. Abraham T3
  50. Belkaya S2
  51. Lorenzo L1
  52. Rosain J1, 16
  53. Bayat M17
  54. Lanternier F1, 16
  55. Lortholary O1, 16
  56. Zakavi F25
  57. Gros P4, 26
  58. Orth G27
  59. Abel L1, 2
  60. Pretet JL19
  61. Fraitag S16
  62. Jouanguy E1, 2
  63. Davis MM28
  64. Tangye SG6, 7
  65. Notarangelo LD12
  66. Marr N14
  67. Waterboer T15
  68. Langlais D4, 26
  69. Doorbar J5
  70. Hovnanian A1, 16
  71. Christensen N3
  72. Bossuyt X18
  73. Shahrooei M18, 22
  74. Casanova JL1, 2, 29
Show Affiliations
Authors Affiliations
  1. 1. University of Paris, Imagine Institute, INSERM U1163, Paris, 75015, France
  2. 2. The Rockefeller University, New York, 10065, NY, United States
  3. 3. Pennsylvania State University College of Medicine, Hershey, 17033, PA, United States
  4. 4. McGill University, Montreal, H3A 0G1, QC, Canada
  5. 5. University of Cambridge, Cambridge, CB2 1QP, UK, United Kingdom
  6. 6. Garvan Institute of Medical Research, Darlinghurst, 2010, NSW, Australia
  7. 7. St. Vincent's Clinical School, UNSW Sydney, Sydney, 2052, NSW, Australia
  8. 8. Isfahan University of Medical Sciences, AIRC, 81746-73461, Isfahan, Iran
  9. 9. Zanjan University of Medical Sciences, Zanjan, 45139-56184, Iran
  10. 10. Stanford University Medical School, Stanford, 94305, CA, United States
  11. 11. Institute for Research in Fundamental Sciences (IPM), Tehran, 19395-5746, Iran
  12. 12. National Institute of Allergy and Infectious Diseases, NIH, Bethesda, 20892, MD, United States
  13. 13. Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, 226-8501, Japan
  14. 14. Sidra Medicine, Doha, Qatar
  15. 15. German Cancer Research Center, Heidelberg, 69120, Germany
  16. 16. Necker Hospital for Sick Children, AP-HP, Paris, 75015, France
  17. 17. Zahedan University of Medical Sciences, Zahedan, 054, Iran
  18. 18. University of Leuven, Leuven, 3000, Belgium
  19. 19. Papillomavirus National Reference Center, Besancon Hospital, Besancon, 25030, France
  20. 20. Thomas Jefferson University, Philadelphia, 19107, PA, United States
  21. 21. Foch Hospital, Suresnes, 92150, France
  22. 22. Dr. Shahrooei Lab, Ahvaz, Iran
  23. 23. University of Southern California, Los Angeles, 90033, CA, United States
  24. 24. Cochin University Hospital, AP-HP, Paris, 75014, France
  25. 25. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 061, Iran
  26. 26. McGill Research Centre on Complex Traits, Montreal, QC H3G 0B1, Canada
  27. 27. Pasteur Institute, Paris, 75015, France
  28. 28. HHMI, Stanford University Medical School, Stanford, 94305, CA, United States
  29. 29. HHMI, New York, 10065, NY, United States

Source: Cell Published:2021


Abstract

We study a patient with the human papilloma virus (HPV)-2-driven “tree-man” phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity. © 2021 Elsevier Inc.
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