Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy

Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy Publisher Pubmed

Eftekhari S^{1, 2} ; Mehvari Habibabadi J^{3, 4} ; Najafi Ziarani M³ ; Hashemi Fesharaki SS³ ; Gharakhani M³ ; Mostafavi H^{5, 6} ; Joghataei MT¹ ; Beladimoghadam N^{3, 7} ; Rahimian E³ ; Hadjighassem MR^{1, 2}

Show Affiliations

1. Cellular and Molecular Research Center, Tehran University of Medical Sciences, School of Advanced Technologies in Medicine, 1417755469 Tehran, Iran
2. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Shefa Neuroscience Research Center, Tehran, Iran
4. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5. Stem Cell Technology Research Center, Molecular Biology and Genetic Engineering Department, Tehran, Iran
6. Zanjan University of Medical Sciences, Zanjan, Iran
7. Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Epilepsia Published:2013

Abstract

Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy. According to our results, seizure frequency was reduced considerably in these patients. Furthermore, epileptiform discharges decreased in two of our patients. If the efficacy of bumetanide is proven in large scale studies, it can be used as a supplemental therapy in temporal lobe epilepsy. © 2012 International League Against Epilepsy.

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Style	Citing Format
MLA	Eftekhari S, et al.. "Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy." Epilepsia, vol. 54, no. 1, 2013, pp. e9-e12.
APA	Eftekhari S, Mehvari Habibabadi J, Najafi Ziarani M, Hashemi Fesharaki SS, Gharakhani M, Mostafavi H, Joghataei MT, Beladimoghadam N, Rahimian E, Hadjighassem MR (2013). Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy. Epilepsia, 54(1), e9-e12.
Chicago	Eftekhari S, Mehvari Habibabadi J, Najafi Ziarani M, Hashemi Fesharaki SS, Gharakhani M, Mostafavi H, Joghataei MT, Beladimoghadam N, Rahimian E, Hadjighassem MR. "Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy." Epilepsia 54, no. 1 (2013): e9-e12.
Harvard	Eftekhari S et al. (2013) 'Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy', Epilepsia, 54(1), pp. e9-e12.
Vancouver	Eftekhari S, Mehvari Habibabadi J, Najafi Ziarani M, Hashemi Fesharaki SS, Gharakhani M, Mostafavi H, et al.. Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy. Epilepsia. 2013;54(1):e9-e12.
BibTex	@article{ author = {Eftekhari S and Mehvari Habibabadi J and Najafi Ziarani M and Hashemi Fesharaki SS and Gharakhani M and Mostafavi H and Joghataei MT and Beladimoghadam N and Rahimian E and Hadjighassem MR}, title = {Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy}, journal = {Epilepsia}, volume = {54}, number = {1}, pages = {e9-e12}, year = {2013} }
RIS	TY - JOUR AU - Eftekhari S AU - Mehvari Habibabadi J AU - Najafi Ziarani M AU - Hashemi Fesharaki SS AU - Gharakhani M AU - Mostafavi H AU - Joghataei MT AU - Beladimoghadam N AU - Rahimian E AU - Hadjighassem MR TI - Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy JO - Epilepsia VL - 54 IS - 1 SP - e9 EP - e12 PY - 2013 ER -

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