P-Glycoprotein Levels in Nasal Secretions of Patients With Non-Polypoid and Polypoid Chronic Rhinosinusitis Publisher



Ar Rezaeian Ahmad REZA ; M Sorkhinejad MAHDIEH ; B Heidari BENTOLHODA
Source: Journal of Isfahan Medical School Published:2025

Abstract

Background: Previous studies have concluded that P-glycoprotein is present not only in cell membranes but also extracellularly. This is because this glycoprotein is overexpressed in certain forms of chronic rhinosinusitis. This study was conducted with the aim of comparing P-glycoprotein levels in different severities of chronic rhinosinusitis with and without polyps. Methods: In this cohort study, 30 patients with non-polypoid chronic rhinosinusitis and 30 patients with polypoid chronic rhinosinusitis were enrolled. The levels of P-glycoprotein in the salivary secretions of the two groups, as well as the severity of rhino sinusitis using the Lund-Mackey, Lund-Kendi, and Nasal Sinus Outcome Test criteria, were measured and compared between the two groups. Findings: The mean P-glycoprotein level in the two groups with and without polyps was 87.24 ± 302.17 and 36.43 ± 224.60, respectively, and the difference between the two groups was significant (P < 0.001). Conclusion: Considering the higher P-glycoprotein level in patients with polypoid chronic rhinosinusitis, it seems that this index can be useful in diagnosing and determining the type of chronic rhinosinusitis. © 2025 Elsevier B.V., All rights reserved.