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Circular Rnas: New Players in Thyroid Cancer Publisher Pubmed



Borran S1 ; Ahmadi G2 ; Rezaei S3 ; Anari MM4 ; Modabberi M5 ; Azarash Z6 ; Razaviyan J7 ; Derakhshan M8 ; Akhbari M9 ; Mirzaei H10
Authors
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Authors Affiliations
  1. 1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biotechnology, Faculty of Science, University of Maragheh, Maragheh, Iran
  3. 3. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical, Sciences, Mashhad, Iran
  4. 4. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Physical Medicine and Rehabilitation Department and Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, School of Medicine, Tehran, Iran
  6. 6. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, School of Medicine Shahid, Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Molecular Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  10. 10. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R., Iran

Source: Pathology Research and Practice Published:2020


Abstract

The prevalence of thyroid cancer the most frequent endocrine malignancy, is rapidly increasing. Most of thyroid cancers are relatively indolent, however, some cases still possess a risk of developing into lethal types of thyroid cancer. Regarding its multistep tumorigenesis, the determination of the underlying mechanisms is a vital issue for thyroid cancer therapy. Circular RNAs (circRNAs) are a type of non-coding RNAs with a closed loop structure. Numerous circRNAs have been identified in cancerous tissues. Mounting data recommends that the biological activities of circRNAs, such as serving as microRNA or ceRNAs sponges, interacting with proteins, modulating gene translation and transcription, suggesting that circRNAs will be potential targets as well as agents for the prognosis and diagnosis of diseases, including cancer. Given that circular RNAs acts as oncogenes or tumor suppressors in the thyroid cancer. Several studies documented that circular RNAs via microRNA and protein sponges could regulate a sequences of cellular and molecular mechanisms e.g., apoptosis, angiogenesis, tumor growth, and invasion that are involved in thyroid cancer pathogenesis. Herein, we summarized the role of circular RNAs as therapeutic and diagnostic biomarkers in the thyroid cancer. Moreover, we highlighted the role of these molecules in the pathogenesis of various cancers. © 2020 Elsevier GmbH
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