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Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Identification and Functional Characterization of Two Novel Srd5a2 Variants in Iranian Siblings With 5Α-Reductase Type 2 Deficiency: Expanding the Mutational Spectrum and Implications for Genetic Diagnosis

Reza Meshkani

Reza Meshkani

Professor of Clinical Biochemistry

Department Biochemistry

School of Medicine

Tehran University of Medical Sciences

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2. Therapeutic Potential of Fisetin in Hepatic Steatosis: Insights Into Autophagy Pathway Regulation and Endoplasmic Reticulum Stress Alleviation in High-Fat Diet-Fed Mice, PLoS ONE (2025)

3. Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non-Alcoholic Fatty Liver Disease, Phytotherapy Research (2025)

4. Combination Therapy of Metformin and Morin Attenuates Insulin Resistance, Inflammation, and Oxidative Stress in Skeletal Muscle of High-Fat Diet-Fed Mice, Phytotherapy Research (2024)

5. Resveratrol Relieves Hfd-Induced Insulin Resistance in Skeletal Muscle Tissue Through Antioxidant Capacity Enhancement and the Nrf2-Keap1 Signaling Pathway, Molecular Biology Reports (2024)

6. The Protective Effects of Fisetin in Metabolic Disorders: A Focus on Oxidative Stress and Associated Events, Journal of Diabetes and Metabolic Disorders (2024)

7. Amelioration of Obesity-Induced White Adipose Tissue Inflammation by Bacillus Coagulans T4 in a High-Fat Diet-Induced Obese Murine Model, Life Sciences (2023)

8. Combination Therapy of Metformin and P-Coumaric Acid Mitigates Metabolic Dysfunction Associated With Obesity and Nonalcoholic Fatty Liver Disease in High-Fat Diet Obese C57bl/6 Mice, Journal of Nutritional Biochemistry (2023)

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13. Metformin-Chlorogenic Acid Combination Reduces Skeletal Muscle Inflammation in C57bl/6 Mice on High-Fat Diets, Molecular Biology Reports (2023)

14. Multiple Novel Functions of Circular Rnas in Diabetes Mellitus, Archives of Physiology and Biochemistry (2023)

15. Principal Component Analysis of Adipose Tissue Gene Expression of Lipogenic and Adipogenic Factors in Obesity, BMC Endocrine Disorders (2023)

16. Resveratrol As a Potential Protective Compound Against Skeletal Muscle Insulin Resistance, Heliyon (2023)

17. The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice, Life Sciences (2023)

18. Chlorogenic Acid Improves Anti-Lipogenic Activity of Metformin by Positive Regulating of Ampk Signaling in Hepg2 Cells, Cell Biochemistry and Biophysics (2022)

19. Metformin Reduces Lipid Accumulation in Hepg2 Cells Via Downregulation of Mir-33B, Archives of Physiology and Biochemistry (2022)

20. Polyphenols: Potential Anti-Inflammatory Agents for Treatment of Metabolic Disorders, Phytotherapy Research (2022)

21. The Role of Protein Tyrosine Phosphatase 1B (Ptp1b) in the Pathogenesis of Type 2 Diabetes Mellitus and Its Complications, Journal of Physiology and Biochemistry (2022)

22. Anti-Inflammatory Effects of Plasma Circulating Exosomes Obtained From Normal-Weight and Obese Subjects on Hepatocytes, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)

23. Combination of Metformin and Chlorogenic Acid Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet Fed Mice, IUBMB Life (2021)

24. Combination of Metformin and Genistein Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Fed Mice, Journal of Nutritional Biochemistry (2021)

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27. Metformin in Combination With Genistein Ameliorates Skeletal Muscle Inflammation in High-Fat Diet Fed C57bl/6 Mice, Cytokine (2021)

28. The Relationship Between Nrf2/Keap1 System and Endoplasmic Reticulum Stress and Inflammatory Markers in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Subjects, Clinical Diabetology (2021)

29. Acetylation and Insulin Resistance: A Focus on Metabolic and Mitogenic Cascades of Insulin Signaling, Critical Reviews in Clinical Laboratory Sciences (2020)

30. Adipose Tissue Mrna Expression of Hdac1, Hdac3 and Hdac9 in Obese Women in Relation to Obesity Indices and Insulin Resistance, Molecular Biology Reports (2020)

31. Close Relationship Between Diabetes and Cancer, Iranian Journal of Public Health (2020)

32. Construction and Functional Characterization of a Fully Human Anti-Mesothelin Chimeric Antigen Receptor (Car) Expressing T Cell, Iranian Journal of Allergy# Asthma and Immunology (2020)

33. Effect of Circulating Exosomes Derived From Normal-Weight and Obese Women on Gluconeogenesis, Glycogenesis, Lipogenesis and Secretion of Fgf21 and Fetuin a in Hepg2 Cells, Diabetology and Metabolic Syndrome (2020)

34. Fatty Acid Synthase and Acetyl-Coa Carboxylase Dysfunction in Visceral Adipose Tissue, Journal of Payavard Salamat (2020)

35. Genetic and Pharmacological Targeting of A2a Receptor Improves Function of Anti-Mesothelin Car T Cells, Journal of Experimental and Clinical Cancer Research (2020)

36. Inhibiting Mir-27A and Mir-142-5P Attenuate Nonalcoholic Fatty Liver Disease by Regulating Nrf2 Signaling Pathway, IUBMB Life (2020)

37. Interplay Between Oxidative Stress and Autophagy Function and Its Role in Inflammatory Cytokine Expression Induced by Palmitate in Skeletal Muscle Cells, Cytokine (2020)

38. Microrna-141 Is Associated With Hepatic Steatosis by Downregulating the Sirtuin1/Amp-Activated Protein Kinase Pathway in Hepatocytes, Journal of Cellular Physiology (2020)

39. Nicotinamide Phosphoribosyltransferase Knockdown Leads to Lipid Accumulation in Hepg2 Cells Through the Sirt1-Ampk Pathway, Cell Journal (2020)

40. Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway, International Journal of Biochemistry and Cell Biology (2020)

41. Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population, Scientific Reports (2020)

42. Resveratrol Reduces Lipid Accumulation Through Upregulating the Expression of Micrornas Regulating Fatty Acid Bet Oxidation in Liver Cells: Evidence From In-Vivo and In-Vitro Studies, Iranian Journal of Pharmaceutical Research (2020)

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45. Therapeutic Effect of Resveratrol Supplementation on Oxidative Stress: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Postgraduate Medical Journal (2020)

46. Association of Carotid Intima Media Thickness With Atherogenic Index of Plasma, Apo B/Apo A-I Ratio and Paraoxonase Activity in Patients With Non-Alcoholic Fatty Liver Disease, Archives of Physiology and Biochemistry (2019)

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48. In-Vitro Synergistic Effect of Metformin and Berberine on High Glucose-Induced Lipogenesis, Iranian Journal of Pharmaceutical Research (2019)

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52. The Role of Micrornas in the Regulation of Insulin Signaling Pathway With Respect to Metabolic and Mitogenic Cascades: A Review, Journal of Cellular Biochemistry (2019)

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54. Correction To: The Effects of Resveratrol on Markers of Oxidative Stress in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial (Acta Diabetologica, (2018), 55, 4, (341-353), 10.1007/S00592-017-1098-3), Acta Diabetologica (2018)

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59. Evidence for the Link Between Defective Autophagy and Inflammation in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Patients, Journal of Physiology and Biochemistry (2018)

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83. Association of Mir-146A Rs2910164 and Mir-149 Rs2292832 Variants With Susceptibility to Type 2 Diabetes, Clinical Laboratory (2016)

84. Decreased Expression of Microrna-21 Is Associated With Increased Cytokine Production in Peripheral Blood Mononuclear Cells (Pbmcs) of Obese Type 2 Diabetic and Non-Diabetic Subjects, Molecular and Cellular Biochemistry (2016)

85. Effects of Resveratrol on Crosstalk Between Canonical B-Catenin/Wnt and Foxo Pathways in Coronary Artery Disease Patients With Metabolic Syndrome: A Case Control Study, Iranian Journal of Pharmaceutical Research (2016)

86. Molecular and Cellular Mechanisms Linking Inflammation to Insulin Resistance and Β-Cell Dysfunction, Translational Research (2016)

87. Tissue Resident Macrophages: Key Players in the Pathogenesis of Type 2 Diabetes and Its Complications, Clinica Chimica Acta (2016)

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