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Cognitive Impairments and Associated Structural Brain Changes in Metabolic Syndrome and Implications of Neurocognitive Intervention Publisher



Kordestanimoghadam P1 ; Assari S2 ; Nouriyengejeh S3 ; Mohammadipour F4 ; Pourabbasi A3
Authors
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Authors Affiliations
  1. 1. Social Determinants of Health Research Center, Lorestan University of Medical Science, Khorramabad, Iran
  2. 2. Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Lorestan University of Medical Science, Khorramabad, Iran

Source: Journal of Obesity and Metabolic Syndrome Published:2021


Abstract

Currently, metabolic syndrome has become a global health problem. Alterations in neurocognitive functions among patients with metabolic syndrome are important issues in this disorder. In this paper, studies on metabolic syndrome were reviewed and their importance emphasized for the benefit of experts and policy makers. Metabolic syndrome activates inflammatory mediators that disrupt brain metabolism. These mediators can be activated by metabolic inflammation and microvascular disorders and may further cause damage to the white matter and impair cognitive function. These alterations can result in serious changes in cognitive abilities. The association between cognitive changes and metabolic syndrome has been independently evaluated in several studies. In addition, some areas of research in the field of metabolic syndrome include the effectiveness of neurocognitive interventions to enhance normal behaviors or reduce risky behaviors in patients. Structural brain correlates of health-related behaviors provide a basis for designing more effective behavioral interventions by identifying the corresponding brain regions and using behavioral interventions. Copyright © 2020 Korean Society for the Study of Obesity