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Metabolic Syndrome in Association With Novel Dietary Index, Metabolic Parameters, Nesfatin-1 and Omentin-1 Publisher Pubmed



Karvane HB1 ; Esfandiari H2 ; Qutaiba O1 ; Allela B3 ; Mahdi MS4 ; Alnuaimi AMA5 ; Alhussein RKA6 ; Jawad MJ7 ; Ghayourvahdat A8 ; Keshavarzian A9
Authors
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Authors Affiliations
  1. 1. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiology Department, Shiraz University of Medical Science of Iran, Shiraz, Iran
  3. 3. College of Pharmacy, Alnoor University, Nineveh, Iraq
  4. 4. College of MLT, Ahl Al Bayt University, Karbala, Iraq
  5. 5. Gilgamesh Ahliya University, Baghdad, Iraq
  6. 6. Collage of Nursing, National University of Science and Technology, Dhi Qar, 64001, Iraq
  7. 7. Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
  8. 8. Inventor member of International Federation of Inventors Associations, Geneva, Switzerland
  9. 9. Golestan University of Medical Science, Gorgan, Iran

Source: BMC Endocrine Disorders Published:2024


Abstract

Background: Metabolic syndrome is a prevalent and common health problem and numerous studies have revealed the role of diet and lifestyle change in prevention of metabolic syndrome. However, the novel dietary index, cardioprotective index (CPI) and its association with metabolic syndrome is not investigated yet. In the current study, we evaluated the association between metabolic syndrome and its components, CPI, Nesfatin-1 and Omentin-1in a cross-sectional study. Methods: Three hundred forty eight overweight and obese individuals with metabolic syndrome were recruited. Subjects underwent anthropometric and laboratory assays including metabolic markers, Nesfatin-1 and Omentin-1 with commercial kits. Results: Those at the first tertile of CPI had lower high density lipoprotein concentrations (HDL) and higher low density lipoprotein concentrations (LDL), triglyceride (TG), systolic and diastolic blood pressures (SBP, DBP) levels compared with those at the highest tertiles (P < 0.05). After adjustment for the confounding effects of age, sex, body mass index, physical activity and total calorie intake, LDL lost its significance across CPI tertiles. Moreover, serum total cholesterol, insulin and insulin resistance were not significant across CPI tertiles neither in crude nor in adjusted models (P > 0.05). Additionally, being at the third tertile of CPI was accompanied with significantly higher Nesfatin-1 and Omentin-1 levels compared with lowest tertiels (P < 0.05) in crude and confounder – adjusted models. Conclusions: To our findings, CPI was in positive relationship with metabolic parameters, blood pressure, Nesfatin-1 and Omentin-1 levels in metabolic syndrome. Further future studies will help to elaborate the causality. Clinical trial number: Not applicable. © The Author(s) 2024.
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