From Multiple Sclerosis to Organ-Specific Autoimmune Disorders: Insights Into the Molecular and Clinical Implications of Comorbidity Publisher Pubmed



Zabihi MR¹ ; Zangooie A^{2, 3} ; Piroozkhah M⁴ ; Harirchian MH⁵ ; Salehi Z⁶ Show Affiliations
Source: Molecular Neurobiology Published:2025

Abstract

Multiple sclerosis (MS) is a complex autoimmune disorder that affects the central nervous system. Although the pathological mechanisms of MS have been extensively studied, its association with other autoimmune diseases, known as comorbidities, remains unclear. In this comprehensive review article, we aim to clarify the cellular and molecular relationship between MS and the incidence of organ-specific autoimmune comorbidities by summarizing former studies. We will explore the commonalities and possible differences between the immune response mechanisms in MS and other autoimmune diseases and provide an overview of the current understanding of the pathophysiological processes involved in the co-occurrence of MS and other organ-specific autoimmune comorbidities. Through this review, we aim to contribute to the development of effective therapeutic strategies that can improve the quality of life of MS patients with comorbidities. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.