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Effects of Magnesium Supplementation on Carotid Intima-Media Thickness and Metabolic Profiles in Diabetic Haemodialysis Patients: A Randomised, Double-Blind, Placebo-Controlled Trial Publisher Pubmed



Talari HR1 ; Zakizade M1 ; Soleimani A2 ; Bahmani F3 ; Ghaderi A4 ; Mirhosseini N5 ; Eslahi M3 ; Babadi M3 ; Mansournia MA6 ; Asemi Z3
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Kashan University of Medical Sciences, PO Box 87159-81151, Kashan, Iran
  2. 2. Department of Internal Medicine, Kashan University of Medical Sciences, PO Box 87159-81151, Kashan, Iran
  3. 3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, PO Box 87159-81151, Kashan, Iran
  4. 4. Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, PO Box 87159-81151, Kashan, Iran
  5. 5. School of Public Health, University of Saskatchewan, Saskatoon, S7N 2Z4, SK, Canada
  6. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417653761, Iran

Source: British Journal of Nutrition Published:2019


Abstract

This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n 27) or placebo (n 27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=-9·42 pmol/l; 95% CI -14·94, -3·90; P=0·001), homoeostasis model of assessment-insulin resistance (β=-0·56; 95 % CI -0·89, -0·24; P=0·001) and HbA1c (β=-0·74 %; 95 % CI -1·10, -0·39; P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01; P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=-0·30 mmol/l; 95% CI -0·56, -0·04; P=0·02), LDL-cholesterol (β=-0·29 mmol/l; 95% CI -0·52, -0·05; P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels. © The Authors 2019.
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