Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis

Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis Publisher

Rafieipoor A¹ ; Torkaman M² ; Azaryan F³ ; Tavakoli A⁴ ; Mohammadian MK⁵ ; Kohansal A⁶ ; Shafaei H⁷ ; Mirzaee P⁸ ; Motiee Bijarpasi Z⁹ ; Bahmani P¹⁰ ; Khosravi M¹¹ ; Doaei S¹² ; Gholamalizadeh M¹³

Show Affiliations

1. Master of Nursing, Hormozgan University of Medical Sciences, Hormozgan, Bandar Abbas, Iran
2. Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
3. Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
6. School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
7. School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
8. Department of Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
9. School of Health, Guilan University of Medical Sciences, Rasht, Iran
10. Department of Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran
11. Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
12. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
13. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Nutrition Published:2024

Abstract

Background: Patients undergoing hemodialysis (HD) frequently experience the chronic kidney disease-associated pruritus (CKD-aP). Objective: The aim of this study was to investigate the effectiveness of omega-3 supplementation in the management of CKD-aP in patients undergoing hemodialysis. Methods: In this triple blind, randomized clinical trial, the effect of the omega-3 supplement on uremic CKD-aP was assessed in 112 chronic hemodialysis patients at Caspian Hemodialysis Center in Rasht, Iran. Patients were randomly divided into the intervention group receiving omega-3 supplements (3 g/day) and the control group receiving placebo containing MCT oil for 2 months. Results: Omega-3 supplementation had no effect on CKD-aP. The results did not change after adjusting for age and sex, additional adjustments for weight, height, physical activity, smoking, and alcohol use, additional adjustments for underlying diseases and weight, height, physical activity, smoking, and drinking alcohol, and further adjustments for underlying diseases and biochemical indices. Discussion: Omega-3 supplementation for 2 months had no effect on CKD-aP in patients with CKD. Further studies with longer duration are warranted. Clinical Trial Registration: https://www.irct.ir/trial/66638, IRCT20151226025699N6 Copyright © 2024 Rafieipoor, Torkaman, Azaryan, Tavakoli, Mohammadian, Kohansal, Shafaei, Mirzaee, Motiee Bijarpasi, Bahmani, Khosravi, Doaei and Gholamalizadeh.; (Figure presented.) Copyright © 2024 Rafieipoor, Torkaman, Azaryan, Tavakoli, Mohammadian, Kohansal, Shafaei, Mirzaee, Motiee Bijarpasi, Bahmani, Khosravi, Doaei and Gholamalizadeh.

2. The Effect of Increasing Blood Flow Rate on Severity of Uremic Pruritus in Hemodialysis Patients: A Single Clinical Trial, Journal of the National Medical Association (2018)

3. Evaluation of Antipruritic Effect of Melatonin on Hemodialysis Patients With Uremic Pruritus, a Double-Blind, Randomized, Crossover Trial, Iranian Journal of Kidney Diseases (2021)

Experts (# of related papers)

View all Related Experts

Soha Namazi (1)

Mahboob Lessan Pezeshki (1)

Style	Citing Format
MLA	Rafieipoor A, et al.. "Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis." Frontiers in Nutrition, vol. 11, no. , 2024, pp. -.
APA	Rafieipoor A, Torkaman M, Azaryan F, Tavakoli A, Mohammadian MK, Kohansal A, Shafaei H, Mirzaee P, Motiee Bijarpasi Z, Bahmani P, Khosravi M, Doaei S, Gholamalizadeh M (2024). Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis. Frontiers in Nutrition, 11(), -.
Chicago	Rafieipoor A, Torkaman M, Azaryan F, Tavakoli A, Mohammadian MK, Kohansal A, Shafaei H, et al.. "Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis." Frontiers in Nutrition 11, no. (2024): -.
Harvard	Rafieipoor A et al. (2024) 'Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis', Frontiers in Nutrition, 11(), pp. -.
Vancouver	Rafieipoor A, Torkaman M, Azaryan F, Tavakoli A, Mohammadian MK, Kohansal A, et al.. Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis. Frontiers in Nutrition. 2024;11():-.
BibTex	@article{ author = {Rafieipoor A and Torkaman M and Azaryan F and Tavakoli A and Mohammadian MK and Kohansal A and Shafaei H and Mirzaee P and Motiee Bijarpasi Z and Bahmani P and Khosravi M and Doaei S and Gholamalizadeh M}, title = {Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis}, journal = {Frontiers in Nutrition}, volume = {11}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Rafieipoor A AU - Torkaman M AU - Azaryan F AU - Tavakoli A AU - Mohammadian MK AU - Kohansal A AU - Shafaei H AU - Mirzaee P AU - Motiee Bijarpasi Z AU - Bahmani P AU - Khosravi M AU - Doaei S AU - Gholamalizadeh M TI - Effectiveness of Omega-3 Fatty Acid Supplementation for Pruritus in Patients Undergoing Hemodialysis JO - Frontiers in Nutrition VL - 11 IS - SP - EP - PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract