The Effect of Anodal and Cathodal Tdcs on Acquisition, of Fear Extinction Memory in Lpfc and Rpfc Regions of Male Mice.



Vahed MR¹ ; Nasehi M^{1, 2} ; Zarrindast MR^{1, 3} Show Affiliations
Source: Annals of Tropical Medicine and Public Health Published:2018

Abstract

Considering to the importance of fear memory in the creation of many mental disorders and the role that fear extinction memory can play in treatment of these disorders. In recent years, increasing research has been done on the affecting factors in the various stages of fear extinction memory formation. On the other hands, several studies indicated that tDCS can alter some of cognitive behaviors such as memory impairment and dementia. So in this study, we have investigated the effects of tDCS on the acquisition of fear extinction memory. In the study 80 male mice (NMRI) were randomly selected and divided into two arms, including LPFC and RPFC arms. Each arm was divided into four subgroups including control, sham, anodal and cathodal stimulation groups. Special electrodes were placed on the mice skull by stereotaxic apparatus on PFC regions. Then by using the tDCS device, electrical stimulation (0.2 mA, 4TD) was applied, according to the special protocol of tDCS application. Statistical analysis showed that anodal tDCS in the LPFC was caused augmentation of fear extinction memory in the acquisition stage while cathodal tDCS in the LPFC could cause debilitation of the fear extinction memory in the acquisition (weakly) .Anodal and Cathodal tDCS in the RPFC did not show any effect on fear extinction memory formation.. It seem that anodal and cathodal tDCS affects more on the left hemisphere LPFC. © 2018 Wolters Kluwer Medknow Publications. All rights reserved.