Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
How Do Stupendous Cannabinoids Modulate Memory Processing Via Affecting Neurotransmitter Systems? Publisher Pubmed



Vaseghi S1, 2 ; Nasehi M1 ; Zarrindast MR2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Neuroscience and Biobehavioral Reviews Published:2021


Abstract

In the present study, we wanted to review the role of cannabinoids in learning and memory in animal models, with respect to their interaction effects with six principal neurotransmitters involved in learning and memory including dopamine, glutamate, GABA (γ-aminobutyric acid), serotonin, acetylcholine, and noradrenaline. Cannabinoids induce a wide-range of unpredictable effects on cognitive functions, while their mechanisms are not fully understood. Cannabinoids in different brain regions and in interaction with different neurotransmitters, show diverse responses. Previous findings have shown that cannabinoids agonists and antagonists induce various unpredictable effects such as similar effect, paradoxical effect, or dualistic effect. It should not be forgotten that brain neurotransmitter systems can also play unpredictable roles in mediating cognitive functions. Thus, we aimed to review and discuss the effect of cannabinoids in interaction with neurotransmitters on learning and memory. In addition, we mentioned to the type of interactions between cannabinoids and neurotransmitter systems. We suggested that investigating the type of interactions is a critical neuropharmacological issue that should be considered in future studies. © 2020 Elsevier Ltd
Related Docs
View other Related Docs
1. Modulating Role of Serotonergic Signaling in Sleep and Memory, Pharmacological Reports (2022)
2. The Interaction Effect of Sleep Deprivation and Cannabinoid Type 1 Receptor in the Ca1 Hippocampal Region on Passive Avoidance Memory, Depressive-Like Behavior and Locomotor Activity in Rats, Behavioural Brain Research (2021)
3. Involvement of Medial Prefrontal Cortex Alpha-2 Adrenoceptors on Memory Acquisition Deficit Induced by Arachidonylcyclopropylamide, a Cannabinoid Cb1 Receptor Agonist, in Rats; Possible Involvement of Ca2+ Channels, Journal of Psychopharmacology (2016)
4. Dorsal Hippocampal Cannabinergic and Gabaergic Systems Modulate Memory Consolidation in Passive Avoidance Task, Brain Research Bulletin (2018)
5. Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin, Behavioural Brain Research (2021)
6. Interaction Between Nmda and Cb2 Function in the Dorsal Hippocampus on Memory Consolidation Impairment: An Isobologram Analysis, Psychopharmacology (2017)
7. Possible Involvement of the Ca1 Gabaergic System on Harmaline Induced Memory Consolidation Deficit, Brain Research Bulletin (2017)
8. The Interaction Between Hippocampal Gaba-B and Cannabinoid Receptors Upon Spatial Change and Object Novelty Discrimination Memory Function, Psychopharmacology (2017)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (5)
Seyed Mohammad Tavangar (3)
Other Related Docs
9. The Effect of Gaba-B Receptors in the Basolateral Amygdala on Passive Avoidance Memory Impairment Induced by Mk-801 in Rats, Behavioural Brain Research (2021)
10. Modulation of the Effects of the Cannabinoid Agonist, Acpa, on Spatial and Non-Spatial Novelty Detection in Mice by Dopamine D1 Receptor Drugs Infused Into the Basolateral Amygdala, Behavioural Brain Research (2015)
11. Possible Involvement of the Ca1 Gabaa Receptors Upon Acquisition and Expression of the Acpa-Induced Place Preference in Mice, Physiology and Behavior (2016)
12. Bidirectional Influence of Amygdala Β1-Adrenoceptors Blockade on Cannabinoid Signaling in Contextual and Auditory Fear Memory, Journal of Psychopharmacology (2018)
13. Synergistic Effect Between Prelimbic 5-Ht3 and Cb1 Receptors on Memory Consolidation Deficit in Adult Male Sprague-Dawley Rats: An Isobologram Analysis, Neuroscience (2016)
14. Role of Ca1 Gabaa and Gabab Receptors on Learning Deficit Induced by D-Ap5 in Passive Avoidance Step-Through Task, Brain Research (2018)
15. Modulation of Cannabinoid Signaling by Hippocampal 5-Ht4 Serotonergic System in Fear Conditioning, Journal of Psychopharmacology (2016)
16. The Role of 5-Ht4 Serotonin Receptors in the Ca1 Hippocampal Region on Memory Acquisition Impairment Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Physiology and Behavior (2020)
17. Interaction Between Hippocampal Serotonin and Cannabinoid Systems in Reactivity to Spatial and Object Novelty Detection, Behavioural Brain Research (2017)
18. Activation of Endocannabinoid System in the Rat Basolateral Amygdala Improved Scopolamine-Induced Memory Consolidation Impairment, Behavioural Brain Research (2016)
19. Synergistic Effect Between D-Ap5 and Muscimol in the Nucleus Accumbens Shell on Memory Consolidation Deficit in Adult Male Wistar Rats: An Isobologram Analysis, Neurobiology of Learning and Memory (2017)
20. The Role of Ca3 Gabab Receptors on Anxiolytic-Like Behaviors and Avoidance Memory Deficit Induced by D-Ap5 With Respect to Ca2 + Ions, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
21. The Modulatory Role of Dopamine in Anxiety-Like Behavior, Archives of Iranian Medicine (2015)
22. Effect of Nucleus Accumbens Shell 5-Ht4 Receptors on the Impairment of Acpa-Induced Emotional Memory Consolidation in Male Wistar Rats, Behavioural Pharmacology (2016)
23. Dopamine As a Potential Target for Learning and Memory: Contributing to Related Neurological Disorders, CNS and Neurological Disorders - Drug Targets (2023)
24. Additive Effect of Harmane and Muscimol for Memory Consolidation Impairment in Inhibitory Avoidance Task, Neuroscience (2016)
25. Nmda Receptor Adjusted Co-Administration of Ecstasy and Cannabinoid Receptor-1 Agonist in the Amygdala Via Stimulation of Bdnf/Trk-B/Creb Pathway in Adult Male Rats, Brain Research Bulletin (2017)
26. Additive Effect of Bla Gabaa Receptor Mechanism and (+)-Mk-801 on Memory Retention Deficit, an Isobologram Analysis, Pharmacology Biochemistry and Behavior (2016)
27. Different Role of Ca1 5Ht3 Serotonin Receptors on Memory Acquisition Deficit Induced Total(Tsd) and Rem Sleep Deprivation(Rsd), Archives of Iranian Medicine (2017)
28. The Involvement of Medial Septum 5-Ht1 and 5-Ht2 Receptors on Acpa-Induced Memory Consolidation Deficit: Possible Role of Trpc3, Trpc6 and Trpv2, Journal of Psychopharmacology (2015)
29. Role of the Amygdala Gaba-A Receptors in Acpa-Induced Deficits During Conditioned Fear Learning, Brain Research Bulletin (2017)
30. The Effect of Ca1 Dopaminergic System in Harmaline-Induced Amnesia, Neuroscience (2015)
31. Synergistic But Not Additive Effect Between Acpa and Lithium in the Dorsal Hippocampal Region on Spatial Learning and Memory in Rats: Isobolographic Analyses, Chemico-Biological Interactions (2020)
32. Interplay Between Serotonin and Cannabinoid Function in the Amygdala in Fear Conditioning, Brain Research (2016)
33. The Bidirectional Effect of Prelimbic 5-Hydroxytryptamine Type-4 (5-Ht4) Receptors on Acpa-Mediated Aversive Memory Impairment in Adult Male Sprague-Dawley Rats, Iranian Journal of Basic Medical Sciences (2021)
34. Interaction Between Harmane, a Class of Β-Carboline Alkaloids, and the Ca1 Serotonergic System in Modulation of Memory Acquisition, Neuroscience Research (2017)
35. The Effect of Bla Gabab Receptors in Anxiolytic-Like Effect and Aversive Memory Deficit Induced by Acpa, Tehran University Medical Journal (2016)
36. Involvement of the Serotonergic System of the Ventral Hippocampus (Ca3) on Amnesia Induced by Acpa in Mice, Behavioural Brain Research (2015)
37. The Effect of 5-Ht4 Serotonin Receptors in the Ca3 Hippocampal Region on D-Ap5-Induced Anxiolytic-Like Effects: Isobolographic Analyses, Behavioural Brain Research (2021)
38. Precondition of Right Frontal Region With Anodal Tdcs Can Restore the Fear Memory Impairment Induced by Acpa in Male Mice, EXCLI Journal (2017)
39. The Hippocampal Nmda Receptors May Be Involved in Acquisition, But Not Expression of Acpa-Induced Place Preference, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2015)
40. Possible Interaction Between the Ventral Hippocampal Cannabinoid Cb2 and Muscarinic Acetylcholine Receptors on the Modulation of Memory Consolidation in Mice, NeuroReport (2020)
41. Gaba-Cannabinoid Interplays in the Dorsal Hippocampus and Basolateral Amygdala Mediate Morphine-Induced Amnesia, Brain Research Bulletin (2020)
42. The Dual Effect of Ca1 Nmda Receptor Modulation on Acpa-Induced Amnesia in Step-Down Passive Avoidance Learning Task, European Neuropsychopharmacology (2015)
43. Therapeutic Attributes of Endocannabinoid System Against Neuro-Inflammatory Autoimmune Disorders, Molecules (2021)
44. The Modulatory Effect of Ca1 Gabab Receptors on Ketamine-Induced Spatial and Non-Spatial Novelty Detection Deficits With Respect to Ca2+, Neuroscience (2015)
45. Neurotransmission Systems in Parkinson's Disease, Reviews in the Neurosciences (2017)
46. Intricate Role of Sleep Deprivation in Modulating Depression: Focusing on Bdnf, Vegf, Serotonin, Cortisol, and Tnf-Α, Metabolic Brain Disease (2023)
47. Dorsal Hippocampal Nmda Receptors Mediate the Interactive Effects of Arachidonylcyclopropylamide and Mdma/Ecstasy on Memory Retrieval in Rats, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2016)
48. Role of the Basolateral Amygdala Dopamine Receptors in Arachidonylcyclopropylamide-Induced Fear Learning Deficits, Psychopharmacology (2016)
49. Harmaline-Induced Amnesia: Possible Role of the Amygdala Dopaminergic System, Neuroscience (2016)
50. The Role of Cannabinoid 1 Receptor in the Nucleus Accumbens on Tramadol Induced Conditioning and Reinstatement, Life Sciences (2020)