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Bidirectional Influence of Amygdala Β1-Adrenoceptors Blockade on Cannabinoid Signaling in Contextual and Auditory Fear Memory Publisher Pubmed



Nasehi M1 ; Shahbazzadeh S2 ; Ebrahimighiri M3 ; Zarrindast MR4, 5, 6
Authors
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Authors Affiliations
  1. 1. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Iran
  2. 2. Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  3. 3. Department of Biology, Faculty of Sciences, University of Zanjan, Iran
  4. 4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran
  5. 5. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Iran
  6. 6. Institute for Cognitive Science Studies (ICSS), Tehran, Iran

Source: Journal of Psychopharmacology Published:2018


Abstract

The basolateral amygdala (BLA) is a major target and modulator of stress and has a critical role in the neural circuitry presenting learned fear behaviors. On the other hand, both the endocannabinoid and noradrenergic systems may be involved in regulating the stress responses, fear, and anxiety. Considering the aforementioned, we have investigated the involvement of the BLA β1-adrenoceptors in conditioned fear responses induced by ACPA, a CB1 receptor (CB1R) agonist. In adult male NMRI mice, freezing responses to context and cue were measured using a Pavlovian fear conditioning apparatus. Pre-training intra-BLA microinjection of xamoterol (0.01 and 0.02 µg/mouse), a partial β1-adrenoceptor agonist, or atenolol (0.5 µg/mouse), a β1-adrenoceptor antagonist, decreased freezing behavior, which suggests an impairment of contextual and auditory fear retrieval. Similar results were found with pre-training intraperitoneal administration of ACPA (0.5 mg/kg). A sub-threshold dose of xamoterol, infused into the BLA, decreased ACPA (0.005 and 0.05 mg/kg) effect on both memories, while atenolol increased ACPA response to the context at the middle dose and decreased ACPA response to the tone at the lower dose. It can be concluded that the blockade of BLA β1-adrenoceptors differentially affects ACPA response on the contextual and auditory conditioned fear memories. © The Author(s) 2018.
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