Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes

Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes Publisher

Mohsenipour R ; Abbasi F ; Ghaderian M S ; Dehkordi A K ; Abdolahpour S ; Akbari K

Source: Endocrinology, Diabetes and Metabolism Published:2026

Abstract

Background: Achieving euglycemia in Glycogen Storage Diseases (GSD) depends on strict dietary adherence; however, intermittent monitoring frequently fails to detect rapid hypoglycemic excursions. This systematic review evaluates the clinical utility, accuracy and psychosocial impact of Continuous Glucose Monitoring (CGM) across hepatic GSD subtypes. Methods: We searched PubMed, Embase, Scopus, Web of Science and Cochrane Library (inception to December 2025) following PRISMA 2020 guidelines. Eligible studies included randomized trials, cohorts and case series reporting CGM outcomes in hepatic GSD. Results: Thirty-one studies (N = 323) met inclusion criteria, predominantly GSD Ia, Ib and III. CGM consistently identified asymptomatic hypoglycemia, with adult cohorts spending up to 12% of time below range (< 70 mg/dL) despite normal spot checks. In interventional settings, CGM-guided dietary titration improved Time in Range (e.g., 72%–86% in gene therapy trials) and reduced serum triglycerides and liver size. However, sensor performance showed a positive bias in the hypoglycemic range, potentially masking severe neuroglycopenia. Psychosocially, while CGM improved sleep quality scores, it introduced ‘alarm fatigue’ from false-positive alerts. Conclusion: Emerging evidence suggests that CGM may shift GSD management from reactive treatment to proactive stabilization. It offers superior sensitivity for detecting occult hypoglycemia and guiding therapy, though its utility is tempered by sensor inaccuracy at lower limits and the burden of constant surveillance. Future implementation requires subtype-specific interpretation and sensors optimized for the hypoglycemic range. © 2026 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.

Style	Citing Format
MLA	Mohsenipour R, et al.. "Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes." Endocrinology, Diabetes and Metabolism, vol. 9, no. 4, 2026, pp. -.
APA	Mohsenipour R, Abbasi F, Ghaderian M S, Dehkordi A K, Abdolahpour S, Akbari K (2026). Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes. Endocrinology, Diabetes and Metabolism, 9(4), -.
Chicago	Mohsenipour R, Abbasi F, Ghaderian M S, Dehkordi A K, Abdolahpour S, Akbari K. "Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes." Endocrinology, Diabetes and Metabolism 9, no. 4 (2026): -.
Harvard	Mohsenipour R et al. (2026) 'Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes', Endocrinology, Diabetes and Metabolism, 9(4), pp. -.
Vancouver	Mohsenipour R, Abbasi F, Ghaderian M S, Dehkordi A K, Abdolahpour S, Akbari K. Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes. Endocrinology, Diabetes and Metabolism. 2026;9(4):-.
BibTex	@article{ author = {Mohsenipour R and Abbasi F and Ghaderian M S and Dehkordi A K and Abdolahpour S and Akbari K}, title = {Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes}, journal = {Endocrinology, Diabetes and Metabolism}, volume = {9}, number = {4}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Mohsenipour R AU - Abbasi F AU - Ghaderian M S AU - Dehkordi A K AU - Abdolahpour S AU - Akbari K TI - Continuous Glucose Monitoring in Glycogen Storage Diseases: A Systematic Review of Clinical Utility, Accuracy and Patient Outcomes JO - Endocrinology, Diabetes and Metabolism VL - 9 IS - 4 SP - EP - PY - 2026 ER -

Science Communicator Platform

Authors

Abstract