Retinoic Acid Receptor-ß, From Gene to Clinic

Retinoic Acid Receptor-ß, From Gene to Clinic Publisher

Fazilaty H¹ ; Mehdipour P²

Show Affiliations

1. Instituto de Neurociencias CSIC-UMH, Avda. Ramon y Cajal s/n, San Juan de Alicante, 03550, Spain
2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Street, P.O. Box: 14176-13151, Keshavarz Boulevard, Tehran, Iran

Source: Epigenetics Territory and Cancer Published:2015

Abstract

Retinoic acid receptor-beta (RAR-ß) is nuclear receptor which can be activated by corresponding ligands, including retinoic acid. It is encoded by RARB gene, which is conserved in several species, and code for a DNA binding protein that in complex to the ligand and other binding partners binds to specific sites and regulates the expression of several genes. RAR-ß plays important roles in several developmental, physiologic, and pathogenic mechanisms in human. It is a tumor suppressor gene, which is not expressed in several cancers. Methylation status and micro-RNAs are key central regulators of the RARB expression, which are influenced by several factors, such as environment and diet. It is responsible for the induction of apoptosis, and for the chemo-preventive and therapeutic effects of anti-cancer drugs, therefor has been used a treatment against different kinds of cancer in several clinical trials. © Springer Science+Business Media Dordrecht 2015.

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Style	Citing Format
MLA	Fazilaty H, Mehdipour P. "Retinoic Acid Receptor-ß, From Gene to Clinic." Epigenetics Territory and Cancer, vol. , no. , 2015, pp. 363-372.
APA	Fazilaty H, Mehdipour P (2015). Retinoic Acid Receptor-ß, From Gene to Clinic. Epigenetics Territory and Cancer, (), 363-372.
Chicago	Fazilaty H, Mehdipour P. "Retinoic Acid Receptor-ß, From Gene to Clinic." Epigenetics Territory and Cancer , no. (2015): 363-372.
Harvard	Fazilaty H, Mehdipour P (2015) 'Retinoic Acid Receptor-ß, From Gene to Clinic', Epigenetics Territory and Cancer, (), pp. 363-372.
Vancouver	Fazilaty H, Mehdipour P. Retinoic Acid Receptor-ß, From Gene to Clinic. Epigenetics Territory and Cancer. 2015;():363-372.
BibTex	@article{ author = {Fazilaty H and Mehdipour P}, title = {Retinoic Acid Receptor-ß, From Gene to Clinic}, journal = {Epigenetics Territory and Cancer}, volume = {}, number = {}, pages = {363-372}, year = {2015} }
RIS	TY - JOUR AU - Fazilaty H AU - Mehdipour P TI - Retinoic Acid Receptor-ß, From Gene to Clinic JO - Epigenetics Territory and Cancer VL - IS - SP - 363 EP - 372 PY - 2015 ER -

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Abstract