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Roles of Non-Coding Rnas in Cell Death Pathways Involved in the Treatment of Resistance and Recurrence of Cancer Publisher Pubmed



Motlagh FM1, 2 ; Kadkhoda S1 ; Motamedrad M3, 4 ; Javidzade P5 ; Khalilian S6, 7 ; Modarressi MH1 ; Ghafourifard S7
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  3. 3. Division of Human Nutrition, University of Alberta, Edmonton, T6G 2P5, AB, Canada
  4. 4. Department of Biology, Faculty of Science, University of Birjand, Birjand, Iran
  5. 5. Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  6. 6. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Considering the burden of cancer, a number of methods have been applied to control or stop it. However, because of drug resistance or cancer recurrence, these treatments usually face failure. Combination of modulation of expression of non-coding RNAs (ncRNAs) with other treatments can increase treatment-sensitivity of tumors but these approaches still face some challenges. Gathering information in this field is a prerequisite to find more efficient cures for cancer. Cancer cells use ncRNAs to enhance uncontrolled proliferation originated from inactivation of cell death routs. In this review article, the main routes of cell death and involved ncRNAs in these routes are discussed. Moreover, extant information in the role of different ncRNAs on cell death pathways involved in the treatment resistance and cancer recurrence is summarized. © 2023 Elsevier GmbH
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