N-Nitrosopyrrolidine Publisher



Ghassemibarghi N^{1, 2} ; Bayrami Z^{1, 2}
Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023

Abstract

N-Nitrosopyrrolidine (NPYR) is one of the N-nitroso compounds (NOCs) involved in human colon and liver carcinogenesis, but the complicated toxicological mechanisms have not been clarified. NPYR may be created while cooking foods with sodium nitrite as a preservative, including fish, cheese, and meat. Other sources of this substance include tobacco smoke and its endogenous type. N-Nitrosopyrrolidine can cause skin and eye irritation and damage organs such as liver and kidney. The primary metabolite of NPYR is 2-hydroxytetrahydrofuran, and its secondary metabolite is some active electrophilic intermediates, which play an essential role in its carcinogenesis. © 2024 Elsevier Inc. All rights reserved.