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Evaluation of Antioxidant Efficacy of Purslane Extract in Patients With Recurrent Aphthous Stomatitis: A Randomized, Placebo-Controlled, Triple-Blinded, Clinical Trial Publisher



Mohammadzadeh M1 ; Rezaei N2 ; Kamran E1 ; Abdolhoseinpour F1 ; Mohammadzadeh M1 ; Moqadam IF4 ; Najafi S5, 6 ; Ahmadabadi MH7
Authors
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Authors Affiliations
  1. 1. Dental Branch, Islamic Azad University, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. North-Khorasan university of medical sciences, Bojnourd, Iran
  4. 4. Private practice, Iran
  5. 5. Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Pharmacy Tehran University of medical sciences, Tehran, Iran

Source: Brazilian Journal of Oral Sciences Published:2016


Abstract

Background: This herbal medicine is considered a rich source of antioxidants with anti-inflammatory effects. The purpose of this study was to evaluate the effectiveness of purslane in treatment of recurrent aphthous stomatitis (RAS) and also it s effect on antioxidant level. Materials and methods: 50 patients were selected for this randomized triple-blind placebo-controlled trial. All subjects were randomly divided in to two groups, one group received purslane (n=25) and another group, placebo (n=25) for 3 month. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and total antioxidant status (TAS) was measured in plasma at baseline and after 3 month of treatment. Also pain intensity based on the visual analogue scale (VAS), the mean interval between lesion, number of lesions and the mean duration of complete healing at baseline and in month 1, 2 and 3 were recorded. Statistical analysis was performed by using Mann-Whitney and T-test. Results: A significant decrease in pain intensity in VAS scores was seen after treatment in intervention group (p < 0.001). The mean duration of complete healing showed significant differences (P < 0.001) between the two groups. The mean interval between lesions also showed significant differences (P < 0.001) among the intervention group (33.12 days) compared with the placebo group (17.88 days). No significant differences were found regarding the number of lesions, level of erythrocyte GSHPx, TAS and SOD. No serious side-effects occurred in either of groups. Conclusions: According to this study, purslane is clinically effective in treatment of RAS (number of lesions, pain intensity and duration of healing) although it is unable to change the level of antioxidants.
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