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Biodistribution Evaluation of 166Ho–Dtpa–Spion in Normal Rats Publisher



Nosrati S1 ; Shanehsazzadeh S2 ; Yousefnia H2 ; Gholami A3 ; Gruttner C4 ; Jalilian AR2 ; Hosseini RH1 ; Lahooti A5
Authors
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Authors Affiliations
  1. 1. Department of Biology, Payame Noor University, Tehran, Iran
  2. 2. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  3. 3. Department of Nuclear Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
  4. 4. Micromod Partikeltechnologie GmbH, Friedrich-Barnewitz-Str. 4, Rostock, 18119, Germany
  5. 5. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016


Abstract

Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho–DTPA–SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho–DTPA–SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15 % of injected dose was in liver and spleen at 30 min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho–DTPA–SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies. © 2015, Akademiai Kiado, Budapest, Hungary.
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