Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study

Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study Publisher

Lahooti A¹ ; Sarkar S^{1, 2} ; Saligheh Rad H^{1, 3} ; Gholami A⁴ ; Nosrati S⁵ ; Muller RN^{6, 7} ; Laurent S^{6, 7} ; Gruttner C⁸ ; Geramifar P⁹ ; Yousefnia H¹⁰ ; Mazidi M¹⁰ ; Shanehsazzadeh S⁶

Show Affiliations

1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
3. Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Nuclear Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
5. Department of Biology, Payame Noor University, Tehran, Iran
6. NMR and Molecular Imaging Laboratory, Department of General, Organic, and Biomedical Chemistry, University of Mons, Mons, Belgium
7. Center for Microscopy and Molecular Imaging (CMMI), Rue Adrienne Bolland 8, Gosselies, 6041, Belgium
8. Micromod Partikeltechnologie GmbH, FriedrichBarnewitz-Str. 4, Rostock, 18119, Germany
9. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
10. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2017

Abstract

The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies. © 2016, Akademiai Kiado, Budapest, Hungary.

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Style	Citing Format
MLA	Lahooti A, et al.. "Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study." Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 1, 2017, pp. 769-774.
APA	Lahooti A, Sarkar S, Saligheh Rad H, Gholami A, Nosrati S, Muller RN, Laurent S, Gruttner C, Geramifar P, Yousefnia H, Mazidi M, Shanehsazzadeh S (2017). Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study. Journal of Radioanalytical and Nuclear Chemistry, 311(1), 769-774.
Chicago	Lahooti A, Sarkar S, Saligheh Rad H, Gholami A, Nosrati S, Muller RN, Laurent S, et al.. "Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study." Journal of Radioanalytical and Nuclear Chemistry 311, no. 1 (2017): 769-774.
Harvard	Lahooti A et al. (2017) 'Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study', Journal of Radioanalytical and Nuclear Chemistry, 311(1), pp. 769-774.
Vancouver	Lahooti A, Sarkar S, Saligheh Rad H, Gholami A, Nosrati S, Muller RN, et al.. Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study. Journal of Radioanalytical and Nuclear Chemistry. 2017;311(1):769-774.
BibTex	@article{ author = {Lahooti A and Sarkar S and Saligheh Rad H and Gholami A and Nosrati S and Muller RN and Laurent S and Gruttner C and Geramifar P and Yousefnia H and Mazidi M and Shanehsazzadeh S}, title = {Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {311}, number = {1}, pages = {769-774}, year = {2017} }
RIS	TY - JOUR AU - Lahooti A AU - Sarkar S AU - Saligheh Rad H AU - Gholami A AU - Nosrati S AU - Muller RN AU - Laurent S AU - Gruttner C AU - Geramifar P AU - Yousefnia H AU - Mazidi M AU - Shanehsazzadeh S TI - Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study JO - Journal of Radioanalytical and Nuclear Chemistry VL - 311 IS - 1 SP - 769 EP - 774 PY - 2017 ER -

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