Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dual Nano-Sized Contrast Agents in Pet/Mri: A Systematic Review Publisher Pubmed



Lahooti A1 ; Sarkar S1 ; Laurent S2, 3 ; Shanehsazzadeh S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Iran
  2. 2. NMR and Molecular Imaging Laboratory, Department of General, Organic, and Biomedical Chemistry, University of Mons, Avenue Maistriau, 19, Mons, B–7000, Belgium
  3. 3. Center for Microscopy and Molecular Imaging (CMMI), Rue Adrienne Bolland, 8, Gosselies, B-6041, Belgium

Source: Contrast Media and Molecular Imaging Published:2016


Abstract

Nowadays molecular imaging plays a vital role in achieving a successful targeted and personalized treatment. Hence, the approach of combining two or more medical imaging modalities was developed. The objective of this review is to systematically compare recent dual contrast agents in Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) and in some cases Single photon emission computed tomography (SPECT)/MRI in terms of some their characteristics, such as tumor uptake, and reticuloendothelial system uptake (especially liver) and their relaxivity rates for early detection of primary cancer tumor. To the best of our knowledge, this is the first systematic and integrated overview of this field. Two reviewers individually directed the systematic review search using PubMed, MEDLINE and Google Scholar. Two other reviewers directed quality assessment, using the criteria checklist from the CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) tool, and differences were resolved by consensus. After reviewing all 49 studies, we concluded that a size range of 20–200 nm can be used for molecular imaging, although it is better to try to achieve as small a size as it is possible. Also, small nanoparticles with a hydrophilic coating and positive charge are suitable as a T2 contrast agent. According to our selected data, the most successful dual probes in terms of high targeting were with an average size of 40 nm, PEGylated using peptides as a biomarker and radiolabeled with copper 64 and gallium 68. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.
Related Docs
View other Related Docs
1. Radiolabeled Theranostics: Magnetic and Gold Nanoparticles, BioImpacts (2016)
2. Development of Ga-68 Labeled, Biotinylated Thiosemicarbazone Dextran-Coated Iron Oxide Nanoparticles As Multimodal Pet/Mri Probe, International Journal of Biological Macromolecules (2020)
3. Biodistribution Evaluation of 166Ho–Dtpa–Spion in Normal Rats, Journal of Radioanalytical and Nuclear Chemistry (2016)
4. Targeted Superparamagnetic Iron Oxide Nanoparticles for Early Detection of Cancer: Possibilities and Challenges, Nanomedicine: Nanotechnology# Biology# and Medicine (2016)
5. Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study, Journal of Radioanalytical and Nuclear Chemistry (2017)
6. Development of 177Lu-Dtpa-Spio Conjugates for Potential Use As a Dual Contrast Spect/Mri Imaging Agent, Radiochimica Acta (2016)
7. Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy, Colloids and Surfaces B: Biointerfaces (2019)
8. Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities, Chemical Reviews (2019)
Experts (# of related papers)
View all Related Experts
Rassoul Dinarvand (10)
Fatemeh Atyabi (9)
Other Related Docs
9. Biomedical Applications of Superparamagnetic Nanoparticles in Molecular Scale, Current Organic Chemistry (2015)
10. Gamma-Ray Involved in Cancer Therapy and Imaging, Electromagnetic Waves-Based Cancer Diagnosis and Therapy: Principles and Applications of Nanomaterials (2023)
11. Biological Identity of Nanoparticles in Vivo: Clinical Implications of the Protein Corona, Trends in Biotechnology (2017)
12. Multiscale Technologies for Treatment of Ischemic Cardiomyopathy, Nature Nanotechnology (2017)
13. Development of Radiolabeled Dextran Coated Iron Oxide Nanoparticles With 111In and Its Biodistribution Studies, International Journal of Radiation Research (2020)
14. Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona, ACS Nano (2016)
15. Superparamagnetic Iron Oxide Nanoparticles for in Vivo Molecular and Cellular Imaging, Contrast Media and Molecular Imaging (2015)
16. Nanoparticles and Biological Environment Interactions, Advanced Structured Materials (2019)
17. Bypassing Protein Corona Issue on Active Targeting: Zwitterionic Coatings Dictate Specific Interactions of Targeting Moieties and Cell Receptors, ACS Applied Materials and Interfaces (2016)
18. Synthetic and Biological Identities of Polymeric Nanoparticles Influencing the Cellular Delivery: An Immunological Link, Journal of Colloid and Interface Science (2019)
19. Unveiling the Theranostic Potential of Spions in Alzheimer's Disease Management, Journal of Psychiatric Research (2024)
20. Monoclonal Antibody Conjugated Magnetic Nanoparticles Could Target Muc-1-Positive Cells in Vitro But Not in Vivo, Contrast Media and Molecular Imaging (2015)
21. Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
22. The Importance of Selecting a Proper Biological Milieu for Protein Corona Analysis in Vitro: Human Plasma Versus Human Serum, International Journal of Biochemistry and Cell Biology (2016)
23. Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics, Cancer Treatment and Research (2015)
24. Disease Specific Protein Corona, Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2015)
25. Comparison of Estimated Human Dose of 68Ga-Maa With 99Mtc-Maa Based on Rat Data, Annals of Nuclear Medicine (2015)
26. Preclinical Evaluation of 68Ga-Maa From Commercial Available 99Mtc-Maa Kit, Iranian Journal of Pharmaceutical Research (2017)
27. The Impact of Protein Corona on the Biological Behavior of Targeting Nanomedicines, International Journal of Pharmaceutics (2022)
28. Protein Corona: Challenges and Opportunities for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments# Tools and Devices (2024)
29. Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles, Nanomedicine (2015)
30. Biomolecular Corona Dictates Aβ Fibrillation Process, ACS Chemical Neuroscience (2018)
31. Protein Corona: Opportunities and Challenges, International Journal of Biochemistry and Cell Biology (2016)
32. Exploring Innovative Strides in Radiolabeled Nanoparticle Progress for Multimodality Cancer Imaging and Theranostic Applications, Cancer Imaging (2024)
33. Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces, Journal of Alzheimer's Disease (2017)
34. Protein Corona Hampers Targeting Potential of Muc1 Aptamer Functionalized Sn-38 Core-Shell Nanoparticles, International Journal of Pharmaceutics (2015)
35. Nanotoxicology: Advances and Pitfalls in Research Methodology, Nanomedicine (2015)
36. 68 Ga-Radiolabeled Bombesin-Conjugated to Trimethyl Chitosan-Coated Superparamagnetic Nanoparticles for Molecular Imaging: Preparation, Characterization and Biological Evaluation, International Journal of Nanomedicine (2019)
37. Mixture Model Based Joint-Map Reconstruction of Attenuation and Activity Maps in Tof-Pet, Journal of Instrumentation (2018)
38. Gold Nanoparticles for Biomedical Imaging and Their Biological Response, New Developments in Gold Nanomaterials Research (2016)
39. Impact of Protein Pre-Coating on the Protein Corona Composition and Nanoparticle Cellular Uptake, Biomaterials (2016)
40. Metal Nanoparticles in Atherosclerosis: Applications and Potential Toxicity, Nano Biomedicine and Engineering (2015)
41. The Bio-Interface Between Functionalized Au Nr@Go Nanoplatforms With Protein Corona and Their Impact on Delivery and Release System, Colloids and Surfaces B: Biointerfaces (2019)
42. Estimated Human Absorbed Dose for 68Ga-Ecc Based on Mice Data: Comparison With 67Ga-Ecc, Annals of Nuclear Medicine (2015)
43. Preclinical Dosimetric Estimation of [111In] 5, 10, 15, 20-Tetra Phenyl Porphyrin Complex As a Possible Imaging/Pdt Agent, Radiochimica Acta (2016)
44. Pegylated Magnetic Mesoporous Silica Nanoparticles Decorated With As1411 Aptamer As a Targeting Delivery System for Cytotoxic Agents, Pharmaceutical Development and Technology (2019)
45. Effect of Coating Thickness of Iron Oxide Nanoparticles on Their Relaxivity in the Mri, Iranian Journal of Basic Medical Sciences (2016)
46. The Most Common Nanostructures As a Contrast Agent in Medical Imaging, Nanomedicine Research Journal (2023)
47. Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery (2015)
48. Toxicity and Biocompatibility of Nanomaterials: In Vivo Studies, Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance (2022)
49. Assessment of Human Effective Absorbed Dose of 67 Ga–Ecc Based on Biodistribution Rat Data, Annals of Nuclear Medicine (2015)
50. The Biomedical Significance of Multifunctional Nanobiomaterials: The Key Components for Site-Specific Delivery of Therapeutics, Life Sciences (2021)