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Shining the Light on Clinical Application of Mesenchymal Stem Cell Therapy in Autoimmune Diseases Publisher Pubmed



Jasim SA1 ; Yumashev AV2 ; Abdelbasset WK3, 4 ; Margiana R5, 6, 7 ; Markov A8, 9 ; Suksatan W10 ; Pineda B11 ; Thangavelu L12 ; Ahmadi SH13
Authors

Source: Stem Cell Research and Therapy Published:2022


Abstract

The autoimmune diseases are associated with the host immune system, chronic inflammation, and immune reaction against self-antigens, which leads to the injury and failure of several tissues. The onset of autoimmune diseases is related to unbalanced immune homeostasis. Mesenchymal stem cells (MSCs) are multipotent cells which have capability to self-renew and differentiate into various cell types that exert a critical role in immunomodulation and regenerative therapy. Under the certain condition in vitro, MSCs are able to differentiate into multiple lineage such as osteoblasts, adipocytes, and neuron-like cells. Consequently, MSCs have a valuable application in cell treatment. Accordingly, in this review we present the last observations of researches on different MSCs and their efficiency and feasibility in the clinical treatment of several autoimmune disorders including rheumatoid arthritis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, autoimmune liver disease, and Sjogren’s syndrome. [Figure not available: see fulltext.]. © 2022, The Author(s).
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