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The Clinical Trials of Mesenchymal Stromal Cells Therapy Publisher



Kouchakian MR1 ; Baghban N2 ; Moniri SF3 ; Baghban M4 ; Bakhshalizadeh S5, 6 ; Najafzadeh V7 ; Safaei Z8 ; Izanlou S9 ; Khoradmehr A2 ; Nabipour I2 ; Shirazi R10 ; Tamadon A2
Authors

Source: Stem Cells International Published:2021


Abstract

Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. MSCs display broad immunomodulatory properties since they are capable of secreting growth factors and chemotactic cytokines. Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. Many studies have been conducted on the application of MSCs as a new therapy, but it seems that a low percentage of them is related to clinical trials, especially completed clinical trials. Considering the importance of clinical trials to develop this type of therapy as a new treatment, the current paper is aimed at describing characteristics of MSCs and reviewing relevant clinical studies registered on the NIH database during 2016-2020 to discuss recent advances on MSC-based therapeutic approaches being used in different diseases. © 2021 Mohammad Reza Kouchakian et al.
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