The Clinical Trials of Mesenchymal Stromal Cells Therapy

The Clinical Trials of Mesenchymal Stromal Cells Therapy Publisher

Kouchakian MR¹ ; Baghban N² ; Moniri SF³ ; Baghban M⁴ ; Bakhshalizadeh S^{5, 6} ; Najafzadeh V⁷ ; Safaei Z⁸ ; Izanlou S⁹ ; Khoradmehr A² ; Nabipour I² ; Shirazi R¹⁰ ; Tamadon A²

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1. Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3. Department of Anatomical Sciences, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5. Reproductive Development, Murdoch Childrenâ€™s Research Institute, Melbourne, VIC, Australia
6. Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
7. Department of Veterinary and Animal Sciences, Anatomy & Biochemistry Section, University of Copenhagen, Copenhagen, Denmark
8. Department of Obstetrics and Gynecology, School of Medicine, Amir Al Moâ€™menin Hospital, Amir Al Moâ€™menin IVF Center, Arak University of Medical Sciences, Arak, Iran
9. Department of Nursing, School of Nursing, Larestan University of Medical Sciences, Larestan, Iran
10. Department of Anatomy, School of Medical Sciences, Medicine & Health, UNSW Sydney, Sydney, Australia

Source: Stem Cells International Published:2021

Abstract

Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. MSCs display broad immunomodulatory properties since they are capable of secreting growth factors and chemotactic cytokines. Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. Many studies have been conducted on the application of MSCs as a new therapy, but it seems that a low percentage of them is related to clinical trials, especially completed clinical trials. Considering the importance of clinical trials to develop this type of therapy as a new treatment, the current paper is aimed at describing characteristics of MSCs and reviewing relevant clinical studies registered on the NIH database during 2016-2020 to discuss recent advances on MSC-based therapeutic approaches being used in different diseases. © 2021 Mohammad Reza Kouchakian et al.

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Style	Citing Format
MLA	Kouchakian MR, et al.. "The Clinical Trials of Mesenchymal Stromal Cells Therapy." Stem Cells International, vol. 2021, no. , 2021, pp. -.
APA	Kouchakian MR, Baghban N, Moniri SF, Baghban M, Bakhshalizadeh S, Najafzadeh V, Safaei Z, Izanlou S, Khoradmehr A, Nabipour I, Shirazi R, Tamadon A (2021). The Clinical Trials of Mesenchymal Stromal Cells Therapy. Stem Cells International, 2021(), -.
Chicago	Kouchakian MR, Baghban N, Moniri SF, Baghban M, Bakhshalizadeh S, Najafzadeh V, Safaei Z, et al.. "The Clinical Trials of Mesenchymal Stromal Cells Therapy." Stem Cells International 2021, no. (2021): -.
Harvard	Kouchakian MR et al. (2021) 'The Clinical Trials of Mesenchymal Stromal Cells Therapy', Stem Cells International, 2021(), pp. -.
Vancouver	Kouchakian MR, Baghban N, Moniri SF, Baghban M, Bakhshalizadeh S, Najafzadeh V, et al.. The Clinical Trials of Mesenchymal Stromal Cells Therapy. Stem Cells International. 2021;2021():-.
BibTex	@article{ author = {Kouchakian MR and Baghban N and Moniri SF and Baghban M and Bakhshalizadeh S and Najafzadeh V and Safaei Z and Izanlou S and Khoradmehr A and Nabipour I and Shirazi R and Tamadon A}, title = {The Clinical Trials of Mesenchymal Stromal Cells Therapy}, journal = {Stem Cells International}, volume = {2021}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Kouchakian MR AU - Baghban N AU - Moniri SF AU - Baghban M AU - Bakhshalizadeh S AU - Najafzadeh V AU - Safaei Z AU - Izanlou S AU - Khoradmehr A AU - Nabipour I AU - Shirazi R AU - Tamadon A TI - The Clinical Trials of Mesenchymal Stromal Cells Therapy JO - Stem Cells International VL - 2021 IS - SP - EP - PY - 2021 ER -

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