Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele

Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele Publisher Pubmed

Lorian K¹ ; Kadkhodaee M¹ ; Kianian F¹ ; Abdi A¹ ; Ranjbaran M¹ ; Ashabi G¹ ; Seifi B¹

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1. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Andrologia Published:2020

Abstract

The main aim of this study was to assay the testicular H2S levels in the varicocele rat model and then to investigate the protective effects of NaHS on morphometric changes, sperm parameters, oxidative stress and apoptosis markers in rat's testis. D,L-propargylglycine (PAG) was administrated to show the effects of cystathionine γ-lyase enzyme (CSE) inhibition in the varicocele. Rats were assigned to four groups: (a) Sham, (b) varicocele, (c) varicocele + PAG and (d) varicocele + NaHS. Animals in varicocele + NaHS group received 30 µmol/L NaHS in drinking water for 56 days. In the varicocele + PAG group, animals received PAG 19 mg/kg twice a week. Morphometric assessment, oxidative stress markers, testicular H2S levels, sperm parameters, TUNEL assay and expression of Bax/Bcl2 were evaluated at the end of experiment. Testicular H2S levels were significantly decreased in varicocele group. NaHS significantly improved sperm parameters, morphometric characteristics and oxidative stress compared to varicocele group. Oxidative stress status deteriorated in the PAG group compared to the varicocele group. This study showed that a low testicular H2S level might play a critical role in male infertility. Thus, NaHS administration may be a promising treatment strategy for male infertility in varicocele. In addition, CSE may not be the only important enzyme in testicular H2S production. © 2019 Blackwell Verlag GmbH

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Mehri Kadkhodaei (6)

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Style	Citing Format
MLA	Lorian K, et al.. "Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele." Andrologia, vol. 52, no. 2, 2020, pp. -.
APA	Lorian K, Kadkhodaee M, Kianian F, Abdi A, Ranjbaran M, Ashabi G, Seifi B (2020). Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele. Andrologia, 52(2), -.
Chicago	Lorian K, Kadkhodaee M, Kianian F, Abdi A, Ranjbaran M, Ashabi G, Seifi B. "Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele." Andrologia 52, no. 2 (2020): -.
Harvard	Lorian K et al. (2020) 'Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele', Andrologia, 52(2), pp. -.
Vancouver	Lorian K, Kadkhodaee M, Kianian F, Abdi A, Ranjbaran M, Ashabi G, et al.. Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele. Andrologia. 2020;52(2):-.
BibTex	@article{ author = {Lorian K and Kadkhodaee M and Kianian F and Abdi A and Ranjbaran M and Ashabi G and Seifi B}, title = {Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele}, journal = {Andrologia}, volume = {52}, number = {2}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Lorian K AU - Kadkhodaee M AU - Kianian F AU - Abdi A AU - Ranjbaran M AU - Ashabi G AU - Seifi B TI - Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele JO - Andrologia VL - 52 IS - 2 SP - EP - PY - 2020 ER -

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