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Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion Publisher



Akhlaghi S1 ; Rabbani S2 ; Karimi H1 ; Haeri A1, 3
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Pharmaceutical Sciences Published:2023


Abstract

Peritoneal adhesions following abdominal procedures remain a major surgical issue. This study aimed to evaluate the preventive effect of curcumin-soybean phosphatidylcholine (CUR-SPC) complex-loaded nanoparticles (NPs) embedded in hyaluronic acid (HA) gel. CUR-SPC complex, CUR-SPC NPs, and CUR-SPC-HA gel were fully characterized regarding particle size, zeta potential, morphology, XRD, FTIR, in-vitro release, and rheology. The in vivo efficacy was investigated in a rat model of cecum abrasion and sidewall defect. The optimized spherical-shaped CUR-SPC NPs had a high CUR loading with nanometric particle size (93 nm). CUR-SPC-HA gel showed a pseudoplastic behavior with a homogeneous distribution of CUR-SPC NPs and a sustained release profile over 3 weeks. The inhibitory effect of CUR-SPC-NP-HA gel on fibroblast proliferation and collagen synthesis was evidenced by histopathological (H&E and Masson trichrome staining) and immunohistochemical analyses (vimentin and collagen I expression). Thus, the proposed NP-gel hybrid system could be a promising postoperative anti-adhesion candidate, employing the advantages of CUR, SPC, and HA. © 2022 American Pharmacists Association
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