Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles

Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles Publisher Pubmed

Hosseinpourmoghadam R¹ ; Rabbani S² ; Mahboubi A¹ ; Tabatabai SA³ ; Haeri A^{1, 4}

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1. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran
2. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, 14155-6153, Iran
3. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran
4. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran

Source: Nanomedicine Published:2021

Abstract

Aim: To develop quercetin-loaded poly(caprolactone) (PCL)/soybean phosphatidylcholine (PC) films coated with silver (Ag) to prevent the formation of postoperative adhesions (POA). Materials methods: Films were prepared using the solvent casting method, coated with Ag, and underwent in vitro tests. In vivo studies were conducted employing an animal model of sidewall defect and cecum abrasion. Results: Films showed sustained release behavior of quercetin and Ag. Coating films with Ag improved their antimicrobial activity. In vivo studies confirmed superior antiadhesion properties of films compared with the control groups evaluated by gross observation, histochemical staining and immunohistochemistry analyses. Conclusion: Ag-Q-PCL-PC films are a potential candidate to prevent POA by acting as a sustained release delivery system and physical barrier. © 2021 Future Medicine Ltd.

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Style	Citing Format
MLA	Hosseinpourmoghadam R, et al.. "Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles." Nanomedicine, vol. 16, no. 27, 2021, pp. 2449-2464.
APA	Hosseinpourmoghadam R, Rabbani S, Mahboubi A, Tabatabai SA, Haeri A (2021). Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles. Nanomedicine, 16(27), 2449-2464.
Chicago	Hosseinpourmoghadam R, Rabbani S, Mahboubi A, Tabatabai SA, Haeri A. "Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles." Nanomedicine 16, no. 27 (2021): 2449-2464.
Harvard	Hosseinpourmoghadam R et al. (2021) 'Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles', Nanomedicine, 16(27), pp. 2449-2464.
Vancouver	Hosseinpourmoghadam R, Rabbani S, Mahboubi A, Tabatabai SA, Haeri A. Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles. Nanomedicine. 2021;16(27):2449-2464.
BibTex	@article{ author = {Hosseinpourmoghadam R and Rabbani S and Mahboubi A and Tabatabai SA and Haeri A}, title = {Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles}, journal = {Nanomedicine}, volume = {16}, number = {27}, pages = {2449-2464}, year = {2021} }
RIS	TY - JOUR AU - Hosseinpourmoghadam R AU - Rabbani S AU - Mahboubi A AU - Tabatabai SA AU - Haeri A TI - Prevention of Abdominal Adhesion by a Polycaprolactone/Phospholipid Hybrid Film Containing Quercetin and Silver Nanoparticles JO - Nanomedicine VL - 16 IS - 27 SP - 2449 EP - 2464 PY - 2021 ER -

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