Drug-Loaded Electrospun Nanofibrous Sheets As Barriers Against Postsurgical Adhesions in Mice Model Publisher



Boroumand S¹ ; Hosseini S² ; Salehi M² ; Faridimajidi R¹ Show Affiliations
Source: Nanomedicine Research Journal Published:2017

Abstract

Objective(s): Postsurgical adhesion is one of the common complications after surgery. Some anti-adhesion barriers are commercially available which are not customarily used by physicians as much as expected because of ineffectiveness. Recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. In the light of role of inflammation and oxidative stress in adhesion formation, it is supposed that curcumin as an anti-oxidant and anti-inflammatory agent is able to prevent postsurgical adhesions. Methods: In the present study, curcumin-loaded nanofibrous sheets were prepared using electrospinning and evaluated for its anti-adhesion profile in a mice model. Scanning Electron Microscopy (SEM), Attenuated Total Reflectance Fourier Transformed Infrared Spectroscopy (ATR-FTIR), drug release and degradation investigations and also, in vivo studies were performed. Results: curcumin-loaded nanofibers were successfully prepared and shown significant prevention of postsurgical adhesion formation in mice model. Release study indicated that after 30 days, about 30% of the drug is released from the electrospun nanofibers. In vivo experiments showed that postsurgical adhesion has been reduced about 50% compared to the control group. Conclusions: Curcumin-loaded nanofibers have the potential to decrease postsurgical adhesion formation as a barrier. This system supports the sustained release of curcumin from the nanofibers. © 2017 Tehran University of Medical Sciences. All rights reserved.