Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer

Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer Publisher Pubmed

Summary: Could polyphenols be the answer against skin cancer metastasis? Research indicates they modulate key pathways for melanoma treatment, unlocking new therapeutic strategies. #CancerResearch #Polyphenols

Sajadimajd S¹ ; Bahramsoltani R^{2, 3} ; Iranpanah A⁴ ; Kumar Patra J⁵ ; Das G⁵ ; Gouda S⁶ ; Rahimi R^{2, 3} ; Rezaeiamiri E⁷ ; Cao H⁸ ; Giampieri F⁹ ; Battino M^{9, 10} ; Tundis R¹¹ ; Campos MG^{12, 13} ; Farzaei MH¹⁴ Show All Authors

Sajadimajd S¹
Bahramsoltani R^{2, 3}
Iranpanah A⁴
Kumar Patra J⁵
Das G⁵
Gouda S⁶
Rahimi R^{2, 3}
Rezaeiamiri E⁷
Cao H⁸
Giampieri F⁹
Battino M^{9, 10}
Tundis R¹¹
Campos MG^{12, 13}
Farzaei MH¹⁴
Xiao J¹⁵

Source: Pharmacological Research Published:2020

Abstract

Polyphenols are one of most important phytochemicals distributing in herb plants, vegetables and fruits, which known as important anticancer agents. Given the high incidence and mortality of skin cancer, this study aimed to uncover the chemopreventive effects of polyphenols against skin cancer metastasis. Electronic databases including Scopus, PubMed, and Cochrane library were used to compile the literature from 2000 to August 2019. Only in vivo mechanistic studies with English full-texts were chosen for this review. Polyphenols were included in this study if they were administered in purified form; while total extract and fractions were excluded. Among the 8254 primarily selected papers, only a final number of 34 studies were included. The chemopreventive effects of polyphenols as anthocyanins, ellagitanins, EGCG, oleuropeindihydroxy phenyl, punicalagin, quercetin, resveratrol and theaflavin, were mainly examined in treatment of melanoma as the highly metastatic form of this cutaneous cancer. Those properties are mediated by modulation of angiogenesis, apoptosis, inflammation, metastasis, proliferation, pathways such as EGFR/MAPK, mTOR/PI3K/Akt, JAK/STAT, FAK/RTK2, PGE-2/VEGF, PGE-1/ERK/HIIF-1α, and modulation of related signals including NF-κB, P21WAF/CIP1, Bim, Bax, Bcl2, Bclx, Bim, Puma, Noxa, ILs and MMPs. Chemopreventive effects of polyphenols are mediated by several signaling pathways against skin carcinogenesis and metastasis, implying the importance of polyphenols to open up new horizons in development of anti-skin cancer therapeutic strategies. © 2019 Elsevier Ltd

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Roodabeh Bahramsoltani (1)

Roja Rahimi (1)

Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer

Style	Citing Format
MLA	Sajadimajd S, et al.. "Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer." Pharmacological Research, vol. 151, no. , 2020, pp. -.
APA	Sajadimajd S, Bahramsoltani R, Iranpanah A, Kumar Patra J, Das G, Gouda S, Rahimi R, Rezaeiamiri E, Cao H, Giampieri F, Battino M, Tundis R, Campos MG, Farzaei MH, Xiao J (2020). Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer. Pharmacological Research, 151(), -.
Chicago	Sajadimajd S, Bahramsoltani R, Iranpanah A, Kumar Patra J, Das G, Gouda S, Rahimi R, et al.. "Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer." Pharmacological Research 151, no. (2020): -.
Harvard	Sajadimajd S et al. (2020) 'Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer', Pharmacological Research, 151(), pp. -.
Vancouver	Sajadimajd S, Bahramsoltani R, Iranpanah A, Kumar Patra J, Das G, Gouda S, et al.. Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer. Pharmacological Research. 2020;151():-.
BibTex	@article{ author = {Sajadimajd S and Bahramsoltani R and Iranpanah A and Kumar Patra J and Das G and Gouda S and Rahimi R and Rezaeiamiri E and Cao H and Giampieri F and Battino M and Tundis R and Campos MG and Farzaei MH and Xiao J}, title = {Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer}, journal = {Pharmacological Research}, volume = {151}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Sajadimajd S AU - Bahramsoltani R AU - Iranpanah A AU - Kumar Patra J AU - Das G AU - Gouda S AU - Rahimi R AU - Rezaeiamiri E AU - Cao H AU - Giampieri F AU - Battino M AU - Tundis R AU - Campos MG AU - Farzaei MH AU - Xiao J TI - Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer JO - Pharmacological Research VL - 151 IS - SP - EP - PY - 2020 ER -

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