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Advances on Natural Polyphenols As Anticancer Agents for Skin Cancer Publisher Pubmed



Sajadimajd S1 ; Bahramsoltani R2, 3 ; Iranpanah A4 ; Kumar Patra J5 ; Das G5 ; Gouda S6 ; Rahimi R2, 3 ; Rezaeiamiri E7 ; Cao H8 ; Giampieri F9 ; Battino M9, 10 ; Tundis R11 ; Campos MG12, 13 ; Farzaei MH14 Show All Authors
Authors
  1. Sajadimajd S1
  2. Bahramsoltani R2, 3
  3. Iranpanah A4
  4. Kumar Patra J5
  5. Das G5
  6. Gouda S6
  7. Rahimi R2, 3
  8. Rezaeiamiri E7
  9. Cao H8
  10. Giampieri F9
  11. Battino M9, 10
  12. Tundis R11
  13. Campos MG12, 13
  14. Farzaei MH14
  15. Xiao J15
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Science, Razi University, Kermanshah, Iran
  2. 2. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, South Korea
  6. 6. Amity Institute of Forestry and Wildlife, Amity University, Noida, Uttar Pradesh, India
  7. 7. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd, Hengqin New Area, Zhuhai, 519031, Guangdong, China
  9. 9. Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo - Vigo Campus, Vigo, Spain
  10. 10. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China
  11. 11. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, Rende, 87036, CS, Italy
  12. 12. Faculty of Pharmacy, University of Coimbra, Heath Sciences Campus, Azinhaga de Santa Comba, Coimbra, Portugal
  13. 13. Coimbra Chemistry Centre (CQC, FCT Unit 313) (FCTUC), University of Coimbra, Rua Larga, Coimbra, Portugal
  14. 14. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  15. 15. Institute of Food Safety and Nutrition, Jinan University, Guangzhou, 510632, China

Source: Pharmacological Research Published:2020


Abstract

Polyphenols are one of most important phytochemicals distributing in herb plants, vegetables and fruits, which known as important anticancer agents. Given the high incidence and mortality of skin cancer, this study aimed to uncover the chemopreventive effects of polyphenols against skin cancer metastasis. Electronic databases including Scopus, PubMed, and Cochrane library were used to compile the literature from 2000 to August 2019. Only in vivo mechanistic studies with English full-texts were chosen for this review. Polyphenols were included in this study if they were administered in purified form; while total extract and fractions were excluded. Among the 8254 primarily selected papers, only a final number of 34 studies were included. The chemopreventive effects of polyphenols as anthocyanins, ellagitanins, EGCG, oleuropeindihydroxy phenyl, punicalagin, quercetin, resveratrol and theaflavin, were mainly examined in treatment of melanoma as the highly metastatic form of this cutaneous cancer. Those properties are mediated by modulation of angiogenesis, apoptosis, inflammation, metastasis, proliferation, pathways such as EGFR/MAPK, mTOR/PI3K/Akt, JAK/STAT, FAK/RTK2, PGE-2/VEGF, PGE-1/ERK/HIIF-1α, and modulation of related signals including NF-κB, P21WAF/CIP1, Bim, Bax, Bcl2, Bclx, Bim, Puma, Noxa, ILs and MMPs. Chemopreventive effects of polyphenols are mediated by several signaling pathways against skin carcinogenesis and metastasis, implying the importance of polyphenols to open up new horizons in development of anti-skin cancer therapeutic strategies. © 2019 Elsevier Ltd
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